2021

Produção científica de docentes e investigadores da ESS | P. PORTO para o ano de 2021.

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Software solutions for stress detection have been emerging. Existing solutions still largely rely on supervised learning methods, requiring extremely large sets of labeled data for each situation. Stress assessment using video plethysmography is a recent method that needs further investigation. The room lighting conditions and the person’s movement have been identified as the main barriers to the software progression. Thus, it is necessary to build a laboratory pilot that will take into account these difficulties. We present an in-depth protocol on how to assess the reliability of a video facial recognition software on collecting physiological data (heart rate and blinking).

Título: An unobtrusive stress detection software: Protocol design to assess the reliability of video plethysmography

Revista: Safety and Health at Work

JCR: 2.707 (2020)

Referência bibliográfica: Ferreira, S., Rodrigues, M., Campos, C., & Rocha, N. (2022). An unobtrusive stress detection software: Protocol design to assess the reliability of video plethysmography. Safety and Health at Work, 13, S309. https://doi.org/10.1016/j.shaw.2021.12.1718

 

 

With the global COVID-19 pandemic, governments from many countries in the world implemented various restrictions to prevent the SARS-Cov-2 virus's spread, including social distancing measures, quarantine, in-home lockdown, and the closure of services and public spaces. This led to an in-creased use of social media platforms to make people feel more connected, but also to maintain physical activity while self-isolating. Concerns about physical appearance and the desire to keep or reach a muscular and toned ideal body, might have further reinforced the engagement in fitness-related social media activities, like sharing progresses in training achievements or following more fitness contents on popular profiles. To better understand the underlying relation among these factors, the present study investigates 729 responses to the Exercise Addiction Inventory (EAI), the Appearance Anxiety Inventory (AAI), the Self-Compassion Scale (SCS) and their association to social media usage and compares the results cross-culturally in five countries (Spain, Lithuania, United Kingdom, Japan, and Hungary). Findings highlight significant differences between males and females, espe-cially in regard to the time spent online (U = 477.5, p = 0.036). Greater levels of appearance anxiety were associated with the exposure to fitness-related contents on social media. These results strongly confirm the previously highlighted association between fitspiration media and body image anxiety predominantly in females. Clinical implications and future considerations in terms of prevention and treatment in a situation of global emergency are also discussed.

Título: An international cross-sectional investigation on social media, fitspiration content exposure, and related risks during the COVID-19 self-isolation period

Revista: Journal of Psychiatric Research

JCR: 4.791 (2020)

Referência bibliográfica: Cataldo, I., Burkauskas, J., Dores, A. R., Carvalho, I. P., Simonato, P., De Luca, I., Gómez-Martínez, M. Á., Melero Ventola, A. R., Demetrovics, Z., Szabo, A., Ábel, K. E., Shibata, M., Kobayashi, K., Fujiwara, H., Arroyo-Anlló, E. M., Martinotti, G., Barbosa, F., Griskova-Bulanova, I., Pranckeviciene, A., Bowden-Jones, H., Esposito, G., & Corazza, O. (2022). An international cross-sectional investigation on social media, fitspiration content exposure, and related risks during the COVID-19 self-isolation period. Journal of Psychiatric Research, 148, 34-44. https://doi.org/10.1016/j.jpsychires.2022.01.032

 

Bisphosphonates are a class of drugs widely used for the treatment of several pathologies associated with increased bone resorption. Although displaying low oral bioavailability, these drugs have the ability to accumulate in bone matrix, where the biological effects are exerted. In the present work, four mono- and dianionic Etidronate-based Organic Salts and Ionic Liquids (Eti-OSILs) were developed by combination of this drug with the superbases 1,1,3,3-tetramethylguanidine (TMG) and 1,5-diazabicyclo(4.3.0)non-5-ene (DBN) as cations, aiming to improve not only the physicochemical properties of this seminal bisphosphonate, but also its efficacy in the modulation of cellular behavior, particularly on human osteoclasts and osteoblasts. It was observed that some of the developed compounds, in particular the dianionic ones, presented very high water solubility and diminished or absent polymorphism. Also, several of them appeared to be more cytotoxic against human breast and osteosarcoma cancer cell lines while retaining low toxicity to normal cells. Regarding bone cells, a promotion of an anabolic state was observed for all Eti-OSILs, primarily for the dianionic ones, which leads to an inhibition of osteoclastogenesis and an increase in osteoblastogenesis. The observed effects resulted from differential modulation of intracellular signaling pathways by the Eti-OSILs in comparison with Etidronate. Hence, these results pave the way for the development of more efficient and bioavailable ionic formulations of bisphosphonates aiming to effectively modulate bone metabolism, particularly in the case of increased bone resorption.

Título: Etidronate-based organic salts and ionic liquids: In vitro effects on bone metabolismo

Revista: International Journal of Pharmaceutics

JCR: 5.875 (2020)

Referência bibliográfica: Teixeira, S., Santos, M. M., Branco, L. C., & Costa-Rodrigues, J. (2021). Etidronate-based organic salts and ionic liquids: In vitro effects on bone metabolism. International Journal of Pharmaceutics, 610, 121262. https://doi.org/10.1016/j.ijpharm.2021.121262

 

The recommended way to assess consciousness in prolonged disorders of consciousness is to observe the patient's responses to sensory stimulation. Multiple assessment sessions have to be completed in order to reach a correct diagnosis. There is, however, a lack of data on how many sessions are sufficient for validity and reliability. The aim of this study was to identify the number of Sensory Modality Assessment and Rehabilitation Technique (SMART) assessment sessions needed to reach a reliable diagnosis. A secondary objective was to identify which sensory stimulation modalities are more useful to reach a diagnosis. A retrospective analysis of all the adult patients (who received a SMART assessment) admitted to a specialist brain injury unit over the course of 4 years was conducted (n = 35). An independent rater analyzed the SMART levels for each modality and session and provided a suggestive diagnosis based on the highest SMART level per session. For the vast majority of patients between 5 and 6 sessions was sufficient to reach the final clinical diagnosis. The visual, auditory, tactile, and motor function modalities were found to be more associated with the final diagnosis than the olfactory and gustatory modalities. These findings provide for the first time a rationale for optimizing the time spent on assessing patients using SMART.

Título: Repeated Clinical Assessment Using Sensory Modality Assessment and Rehabilitation Technique for Diagnosis in Prolonged Disorders of Consciousness

Revista: Frontiers in Human Neuroscience

JCR: 3.169 (2020)

Referência bibliográfica: da Conceição Teixeira, L., Blacker, D., Campos, C., Garrett, C., Duport, S., & Rocha, N. B. (2021). Repeated Clinical Assessment Using Sensory Modality Assessment and Rehabilitation Technique for Diagnosis in Prolonged Disorders of Consciousness [Original Research]. Frontiers in Human Neuroscience, 15. https://doi.org/10.3389/fnhum.2021.728637

  

Ankylosing Spondylitis (AS) is a chronic inflammatory disease, associated to spine moblity limitations. Until today it isn’t known an efficient treatment; although, there are therapeutic strategies, like exercise, that can alleviate and delay the disease complications.

Título: Influence of Exercise on Functional Capacity and in the Lumbar and Thoracic Disability in Ankylosing Spondylitis

Revista: Journal of Rehabilitation Medicine

JCR: 1.595 (2015)

Referência bibliográfica: Lopes, S., Mesquita, C., & Santos, P. (2015). Influence of exercise on functional capacity and in the lumbar and thoracic disability in ankylosing spondylitis. Journal of REHABILITATION MEDICINE 418. https://doi.org/doi:10.2340/16501977-1996

 

Ankylosing spondylitis (AS) is an inflammatory rheumatic disease, associated with limited mobility of the spine, sleep disturbance, and fatigue. The exercise aims are to preserve mobility and decrease sleep disorders.

Título: Effect of Exercise on Quality of Sleep in Patients with Ankylosing Spondylitis

Revista: Journal of Rehabilitation Medicine

JCR: 1.595 (2015)

Referência bibliográfica: Lopes, L., Mesquita, C., & Santos, P. (2015). Effect of Exercise on Quality of Sleep in Patients with Ankylosing Spondylitis. 417-418. https://doi.org/doi:10.2340/16501977-1996

 

The school community is exposed to numerous risk factors for the occurrence of neck pain. These symptoms may cause restrictions on their functional capacity and there’s a need to make a proper measurement of this phenomenon, in a valid and reproducible manner. For this, the most recommended instrument is the Neck Disability Index (NDI); however its use in Portugal requires an analysis of its psychometric properties.

Título: Prevalence of Cervical Pain and Functional Disability in the School Community

Revista: Journal of Rehabilitation Medicine

JCR: 1.595 (2015)

Referência bibliográfica: Mesquita, C., Santos, P., & Lopes, S. (2015). Prevalence of Cervical Pain and Functional Disability in the School Community. Journal of REHABILITATION MEDICINE, 157. https://doi.org/doi:10.2340/16501977-1996

 

Neck disorders appear more often associated with pain and muscle fatigue, both in young individuals and in individuals of middle age. Sustained muscle contraction needed to maintain the head in several positions and fatigue caused by muscle weakness are some of the factors for the arising of neck pain.

Título: Relationship between the Ratio of the Cervical Muscles and Non-Specific Neck Pain in the School Community

Revista: Journal of Rehabilitation Medicine

JCR: 1.595 (2015)

Referência bibliográfica: Mesquita, C., Santos, P., & Lopes, S. (2015). Relationship between the Ratio of the Cervical Muscles and Non-Specific Neck Pain in the School Community. Journal of REHABILITATION MEDICINE 14. https://doi.org/doi: 10.2340/16501977-1996

 

The role of milk and dairy products in supplying iodine to pregnant women is unknown in Portugal. The aim of this study was to evaluate the association between milk and dairy product consumption and the iodine status of pregnant women in the IoMum cohort of the Oporto region. Pregnant women were recruited between 10 and 13 weeks of gestation, when they provided a spot urine sample and information on lifestyle and intake of iodine-rich foods. Urinary iodine concentration (UIC) was determined by inductively coupled plasma MS. A total of 468 pregnant women (269 iodine supplement users and 199 non-supplement users) were considered eligible for analysis. Milk (but not yogurt or cheese) intake was positively associated with UIC, in the whole population (P = 0·02) and in the non-supplement users (P = 0·002), but not in the supplement users (P = 0·29). In non-supplement users, adjusted multinomial logistic regression analysis showed that milk consumption <3 times/month was associated with a five times increased risk of having UIC < 50 µg/l when compared with milk consumption ≥2 times/d (OR 5·4; 95 % CI 1·55, 18·78; P = 0·008). The highest UIC was observed in supplement users who reported consuming milk once per d (160 µg/l). Milk, but not yogurt or cheese, was positively associated with iodine status of pregnant women. Despite the observed positive association, daily milk consumption may not be sufficient to ensure adequate iodine intake in this population.

Título: The association of milk and dairy consumption with iodine status in pregnant women in Oporto region

Revista: British Journal of Nutrition

JCR: 3.718 (2020)

Referência bibliográfica: Ferreira, P., Pinheiro, C., Matta Coelho, C., Guimarães, J., Pereira, G., Xavier Moreira, N., . . . Keating, E. (2021). The association of milk and dairy consumption with iodine status in pregnant women in Oporto region. British Journal of Nutrition, 126(9), 1314-1322. doi:10.1017/S000711452100009X

 

The COVID- 19 pandemic led to striking changes in clinical care delivery and created an opportunity for digital health. Objectives: To characterize physicians’ use of telemedicine for patient follow- up during the first months of the COVID- 19 pandemic, to evaluate physician’s opinion and availability to participate in mHealth- related clinical studies with patient recruitment and assessment via telemedicine and to explore characteristics associated with the openness to participate.

Título: Physicians’ perspective on telemedicine use during the COVID- 19 pandemic: is it feasible to recruit and assess participants in mhealth- related clinical studies?

JCR: 13.146 (2020)

Referência bibliográfica: Pereira, A., Almeida, R., Amaral, R., Alves- Correia, M., Mendes, S., Fonseca, J., & Jácome, C. (2021). Physicians’ perspective on telemedicine use during the COVID- 19 pandemic: is it feasible to recruit and assess participants in mhealth- related clinical studies? Allergy, 76, 189. https://doi.org/DOI: 10.1111/all.15095

 

A incontinência urinária afeta até um terço das mulheres em Portugal. O exercício pode ser fator precipitante/de exacerbação, mas também protetor, se for adequado. O objetivo deste estudo é determinar a prevalência de incontinência urinária em mulheres praticantes de exercício recreativo, avaliar a relação com o tipo de exercício e outros fatores de risco coexistentes, e aferir se o tema é abordado nos ginásios. Material e Métodos: Estudo transversal através de questionários de auto-preenchimento em ginásios do Porto e Vila Nova de Gaia. Resultados: Duzentas e noventa mulheres completaram os questionários. Destas, 67,6% tinham menos de 40 anos, 25,2% referiam incontinência e 53,4% tinham pelo menos um fator de risco não relacionado com exercício. Verificou-se uma associação estatisticamente significativa (p < 0,05) entre incontinência, obesidade e obstipação. Exercícios de alto impacto eram incluídos nos treinos de 62,1% das mulheres continentes e 50,9% das incontinentes. O tema incontinência e fortalecimento muscular do pavimento pélvico foi abordado em apenas 5,5% na avaliação inicial, 9,7% em treinos coletivos e em 13,5% das 37 mulheres com treinos individuais. Discussão: A maior proporção de mulheres continentes, comparativamente às incontinentes, que praticavam exercício extenuante, sugere que este era um fator provocativo para algumas, não se verificando, contudo, uma associação estatisticamente significativa entre incontinência e tipo de exercício. Conclusão: A incontinência urinária afeta mulheres praticantes de exercício recreativo, independentemente da idade e características do exercício. É raramente abordada nos ginásios, sendo necessário sensibilizar os profissionais para potenciar os efeitos preventivos/ terapêuticos do exercício na função do pavimento pélvico e no controlo de fatores de risco modificáveis

Título: A Incontinência Urinária em Mulheres Praticantes de Exercício Recreativo: Um Estudo Transversal

Revista: Acta Médica Portuguesa

JCR: 1.141 (2020)

Referência bibliográfica: Silva, M. F., Costa, R. P., Oliveira, C. M., & Moreira, S. (2021). A incontinência urinária em mulheres praticantes de exercício recreativo: um estudo transversal. Acta Médica Portuguesa, 34, 724 - 732. https://doi.org/10.20344/amp.14004

 

There is a recent trend to place more emphasis on noise non-auditory effects. Despite its implications on health, there is a lack of recommendations for noise in occupational settings. This study aimed to present occupational exposure limits for noise-induced non-auditory effects in healthy males using empirical exposure-response regression models based on the data of laboratory and field considering the effective variables. To this end, the equivalent noise level was measured and recorded in four working settings including closed offices, openplan offices, control rooms, and industrial workplaces during a normal working day. They were 65, 68, 73, and 80dB(A), respectively. In the laboratory, 31 healthy males were exposed to five noise conditions (four noisy conditions and one quiet) during 8 h and they were asked to perform the cognitive tests. In the field phase, 124 healthy males were also examined from four working settings in their workstations for 8 h. The psychophysiological parameters of the participants were recorded in both lab and field. The results indicated variations in mental responses at levels above 55dBA, and psychophysiological variations at levels above 70dB(A) in both phases. The findings also showed that the developed regression models could plausibly predict the noise-induced psychophysiological responses during exposure to noise levels; thus, they can be presented the likely exposure limits. Based on the results of the models, the levels 80dB(A).

Título: Prediction of occupational exposure limits for noise-induced non-auditory effects

Revista: Applied Ergonomics

JCR: 3.661 (2020)

Referência bibliográfica: Golmohammadi, R., Darvishi, E., Shafiee Motlagh, M., Faradmal, J., Aliabadi, M., & Rodrigues, M. A. (2022). Prediction of occupational exposure limits for noise-induced non-auditory effects. Applied Ergonomics, 99, 103641. https://doi.org/10.1016/j.apergo.2021.103641

 

Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

Título: The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Revista: International Journal of Molecular Sciences

JCR: 5.294 (2020)

Referência bibliográfica: Gomes, A., Aguiar, L., Ferraz, R., Teixeira, C., & Gomes, P. (2021). The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years. International Journal of Molecular Sciences, 22(21), 11991. https://www.mdpi.com/1422-0067/22/21/11991

 

Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned aphasia research analyses. Data were collated by systematically identifying existing, eligible studies in any language (≥10 IPD, data on time since stroke, and language performance) and included sourcing from relevant aphasia research networks. We invited electronic contributions and also extracted IPD from the public domain. Data were assessed for completeness, validity of value-ranges within variables, and described according to pre-defined categories of demographic data, therapy descriptions, and language domain measurements. We cleaned, clarified, imputed and standardised relevant data in collaboration with the original study investigators. We presented participant, language, stroke, and therapy data characteristics of the final database using summary statistics. From 5256 screened records, 698 datasets were potentially eligible for inclusion; 174 datasets (5928 IPD) from 28 countries were included, 47/174 RCT datasets (1778 IPD) and 91/174 (2834 IPD) included a speech and language therapy (SLT) intervention. Participants’ median age was 63 years (interquartile range [53, 72]), 3407 (61.4%) were male and median recruitment time was 321 days (IQR 30, 1156) after stroke. IPD were available for aphasia severity or ability overall (n = 2699; 80 datasets), naming (n = 2886; 75 datasets), auditory comprehension (n = 2750; 71 datasets), functional
communication (n = 1591; 29 datasets), reading (n = 770; 12 datasets) and writing (n = 724; 13 datasets). Information on SLT interventions were described by theoretical approach, therapy target, mode of delivery, setting and provider. Therapy regimen was
described according to intensity (1882 IPD; 60 datasets), frequency (2057 IPD; 66 datasets), duration (1960 IPD; 64 datasets) and dosage (1978 IPD; 62 datasets). Our international IPD archive demonstrates the application of big data principles in the context of aphasia research; our rigorous methodology for data acquisition and cleaning can serve as a template for the establishment of similar databases in other research areas.

Título: Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke

Revista: Aphasiology

JCR: 2.773 (2020)

Referência bibliográfica: Williams, L. R., Ali, M., VandenBerg, K., Williams, L. J., Abo, M., Becker, F., Bowen, A., Brandenburg, C., Breitenstein, C., Bruehl, S., Copland, D. A., Cranfill, T. B., Di Pietro-Bachmann, M., Enderby, P., Fillingham, J., Galli, F. L., Gandolfi, M., Glize, B., Godecke, E., Hawkins, N., Hilari, K., Hinckley, J., Horton, S., Howard, D., Jaecks, P., Jefferies, E., Jesus, L. M. T., Kambanaros, M., Kyoung Kang, E., Khedr, E. M., Kong, A. P.-H., Kukkonen, T., Laganaro, M., Lambon Ralph, M. A., Laska, A. C., Leemann, B., Leff, A. P., Ribeiro Lima, R., Lorenz, A., MacWhinney, B., Marshall, R. S., Mattioli, F., Maviş, İ., Meinzer, M., Nilipour, R., Noé, E., Paik, N.-J., Palmer, R., Papathanasiou, I., Patricio, B. F., Pavão Martins, I., Price, C., Prizl Jakovac, T., Rochon, E., Rose, M. L., Rosso, C., Rubi-Fessen, I., Ruiter, M. B., Snell, C., Stahl, B., Szaflarski, J. P., Thomas, S. A., Van De Sandt-Koenderman, M., Van Der Meulen, I., Visch-Brink, E., Worrall, L., Wright, H. H., & Brady, M. C. (2021). Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke. Aphasiology, 1-21. https://doi.org/10.1080/02687038.2021.1897081

 

Social frailty is a complex concept and there is still no consensus on the criteria that best define it, nor on the role that social dimensions play in well-established frailty models. Aim: To analyse the predictive value of social frailty dimensions on distinct frailty models.  A non-probabilistic sample of 193 community-dwelling adults aged 65 years and over was recruited in 2016 and followed for three years. Frailty was assessed by the Tilburg Frailty Indicator, the Groningen Frailty Indicator, and the Fried Phenotype criteria. Questions about living alone, social network, social support, loneliness, and frequency of social activities engagement were used to assess social criteria. Bivariate correlations and sequential multiple hierarchical logistic regression analyses were performed.
At baseline, 22.2% older adults lived alone, 47.2% reported missing people around them, 21.1% reported lack of social support, 26.1% reported having reduced their participation in social activities recently and 52.2% reported loneliness. The percent of frail individuals varied across frailty measures, and social criteria showed significant correlations and increased the prediction of frailty status. Loneliness and social activities engagement were associated with frailty as assessed by the Tilburg frailty Indicator and by the Fried Phenotype criteria; the lack of social support is associated with frailty as assessed by the Groningen Frailty Indicator. Living alone and lack of social relationships did not predict frailty. Including social dimensions in a frailty model needs a consensual theoretical basis as they have different roles in predicting frailty, varying over time and across assessment tools.

Título: Social frailty dimensions and frailty models over time

Revista: Archives of Gerontology and Geriatrics

JCR: 3.250 (2020)

Referência bibliográfica: Bessa, B., Coelho, T., & Ribeiro, Ó. (2021). Social frailty dimensions and frailty models over time. Archives of Gerontology and Geriatrics, 97, 104515. https://doi.org/10.1016/j.archger.2021.104515

 

Recently, kinematic analysis of the drinking task (DRINK) has been recommended to assess the quality of upper limb (UL) movement after stroke, but the accomplishment of this task may become difficult for poststroke patients with hand impairment. Therefore, it is necessary to study ADLs that involve a simpler interaction with a daily life target, such as the turning on a light task (LIGHT). As the knowledge of movement performed by healthy adults becomes essential to assess the quality of movement of poststroke patients, the main goal of this article was to compare the kinematic strategies used by healthy adults in LIGHT with those that are used in DRINK. 63 adults, aged 30 to 69 years old, drank water and turned on a light, using both ULs separately, while seated. The movements of both tasks were captured by a 3D motion capture system. End-point and joint kinematics of reaching and returning phases were analysed. A multifactorial analysis of variance with repeated measures was applied to the kinematic metrics, using age, sex, body mass index and dominance as main factors. Mean and peak velocities, index of curvature, shoulder flexion and elbow extension were lower in LIGHT, which suggests that the real hand trajectory was smaller in this task. In LIGHT, reaching was less smooth and returning was smoother than DRINK. The instant of peak velocity was similar in both tasks. There was a minimal anterior trunk displacement in LIGHT, and a greater anterior trunk displacement in DRINK. Age and sex were the main factors which exerted effect on some of the kinematics, especially in LIGHT. The different target formats and hand contact in DRINK and LIGHT seem to be responsible for differences in velocity profile, efficiency, smoothness, joint angles and trunk displacement. Results suggest that the real hand trajectory was smaller in LIGHT and that interaction with the switch seems to be less demanding than with the glass. Accordingly, LIGHT could be a good option for the assessment of poststroke patients without grasping ability. Age and sex seem to be the main factors to be considered in future studies for a better match between healthy and poststroke adults.

Título: Comparison of upper limb kinematics in two activities of daily living with different handling requirements

Revista: Human Movement Science

JCR: 2.161 (2020)

Referência bibliográfica: Mesquita, I. A., Fonseca, P. F. P. d., Borgonovo-Santos, M., Ribeiro, E., Pinheiro, A. R. V., Correia, M. V., & Silva, C. (2020). Comparison of upper limb kinematics in two activities of daily living with different handling requirements. Human Movement Science, 72, 102632. https://doi.org/https://doi.org/10.1016/j.humov.2020.102632

 

The principal goal of this study was to produce adjusted normative data for European Portuguese native speakers from Portugal on 2 neuropsychological tests widely used to assess learning and memory: the Hopkins Verbal Learning Test-Revised (HVLT-R) and the Rey–Osterrieth Complex Figure Test (ROCF). The study included 300 individuals aged 18–92 years (M = 50.4, SD = 21.2), who had educational backgrounds ranging from 3 to 25 years (M = 10.4, SD = 5.2). Age, education, and sex were significantly associated with HVLT-R and ROCF performance. These demographic variables accounted for 61% of the variance in HVLT-R total recall, 54% in HVLT-R delayed recall, 18% in HVLT-R recognition, 55% in ROCF copy, and 39% in ROCF immediate recall.  The normative data are presented as regression-based algorithms to adjust direct and derived test scores for age, education, and sex. This study provides a calculator of normative data derived from the results of the regression models.

Título: Regression-Based Norms for the Hopkins Verbal Learning Test-Revised and the Rey–Osterrieth Complex Figure in a Portuguese Adult Population

Revista: Archives of Clinical Neuropsychology

JCR: 2.813 (2020)

Referência bibliográfica: Vicente, S. G., Ramos-Usuga, D., Barbosa, F., Gaspar, N., Dores, A. R., Rivera, D., & Arango-Lasprilla, J. C. (2020). Regression-Based Norms for the Hopkins Verbal Learning Test-Revised and the Rey–Osterrieth Complex Figure in a Portuguese Adult Population. Archives of Clinical Neuropsychology, 36(4), 587-596. https://doi.org/10.1093/arclin/acaa087

 

To review the methods used to analyze the kinematics of upper limbs (ULs) of healthy and poststroke adults, namely the motion capture systems and kinematic metrics. A database of articles published in the last decade was compiled using the following search terms combinations: (“upper extremity” OR “upper limb” OR arm) AND (kinematic OR motion OR movement) AND (analysis OR assessment OR measurement). The articles included in this review: (1) had the purpose to analyze objectively three-dimension kinematics of ULs, (2) studied functional movements or activities of daily living involving ULs, and (3) studied healthy and/or poststroke adults. Fourteen articles were included (four studied a healthy sample, three analyzed poststroke patients, and seven examined both poststroke and healthy participants). Most articles used optoelectronic systems with markers; however, the presentation of laboratory and task-specific errors is missing. Markerless systems, used in some studies, seem to be promising alternatives for implementation of kinematic analysis in hospitals and clinics, but the literature proving their validity is scarce. Most articles analyzed “joint kinematics” and “end-point kinematics,” mainly related with reaching. The different stroke locations of the samples were not considered in their analysis and only three articles described their psychometric properties. Future research should validate portable motion capture systems, document their specific error at the acquisition place and for the studied task, include grasping and manipulation analysis, and describe psychometric properties.

Título: Methodological considerations for kinematic analysis of upper limbs in healthy and poststroke adults Part II: a systematic review of motion capture systems and kinematic metrics

Revista: Topics in Stroke Rehabilitation

JCR: 1.897 (2019)

Referência bibliográfica: Inês Albuquerque Mesquita, Pedro Filipe Pereira da Fonseca, Ana Rita Vieira Pinheiro, Miguel Fernando Paiva Velhote Correia & Cláudia Isabel Costa da Silva (2019) Methodological considerations for kinematic analysis of upper limbs in healthy and poststroke adults Part II: a systematic review of motion capture systems and kinematic metrics, Topics in Stroke Rehabilitation, 26:6, 464-472, DOI: 10.1080/10749357.2019.1611221

 

The purpose of this study was to review the methods used to analyze the kinematics of upper limbs (ULs) of healthy and poststroke adults, namely specificities of sampling and motor tasks. A database of articles published in the last decade was compiled using the following search terms combinations: (“upper extremity” OR “upper limb” OR arm) AND (kinematics OR motion OR movement) AND (analysis OR assessment OR measurement). The articles included in this review (1) had the purpose to analyze objectively a three-dimension kinematics of ULs, (2) studied functional movements or activities of daily living (ADL) involving uppers limbs, and (3) studied healthy and/or poststroke adults. Fourteen articles were included (four studied a healthy sample, three analyzed poststroke patients, and seven examined both poststroke and healthy participants).  Most of the recommended demographic and stroke information, such as some preexisting conditions to stroke, initial stroke severity, and stroke location, were not collected by all or most of the articles. Time poststroke onset was presented in all articles but showed great variability. Few articles identified anthropometric characteristics and adjusted task environment to them. Most of the samples were composed mainly by males and had a low mean age, which does not represent poststroke population. Most articles analyzed “functional movements”, namely simulations of ADL.  Future research should identify the recommended information to allow an adequate stratification. Acute phase after stroke, real ADL with different complexities, and ipsilesional UL should be studied.

Título: Methodological considerations for kinematic analysis of upper limbs in healthy and poststroke adults. Part I: A systematic review of sampling and motor tasks

Revista: Topics in Stroke Rehabilitation

JCR: 1.964 (2018)

Referência bibliográfica: Inês Albuquerque Mesquita, Ana Rita Vieira Pinheiro, Miguel Fernando Paiva Velhote Correia & Cláudia Isabel Costa da Silva (2019) Methodological considerations for kinematic analysis of upper limbs in healthy and poststroke adults. Part I: A systematic review of sampling and motor tasks, Topics in Stroke Rehabilitation, 26:2, 142-152, DOI: 10.1080/10749357.2018.1551953

 

The umbilical cord has been proved to be an easy-access, reliable, and useful source of mesenchymal stem cells (MSC) for clinical applications due to its primitive, immunomodulatory, non-immunogenic, secretory and paracrine, migratory, proliferative, and multipotent properties. This set of characteristics has recently attracted great research interest in the fields of nanotechnology and regenerative medicine and cellular therapy. Accumulating evidence supports a pronounced therapeutic potential of MSC in many different pathologies, from hematology to immunology, wound-healing, tissue regeneration, and oncology. Diabetes mellitus, branded the epidemic of the century, is considered a chronic metabolic disorder, representing a major burden for health system sustainability and an important public health challenge to modern societies. The available treatments for type 2 diabetes mellitus (T2DM) still rely mainly on combinations of oral antidiabetic agents with lifestyle and nutritional adjustments. Despite the continuous development of novel and better hypoglycemic drugs, their efficacy is limited in the installment and progression of silent T2DM complications. T2DM comorbidities and mortality rates still make it a serious, common, costly, and long-term manageable disease. Recently, experimental models, preclinical observations, and clinical studies have provided some insights and preliminary promising results using umbilical cord MSCs to treat and manage diabetes. This review focuses on the latest research and applications of human-derived umbilical cord MSC in the treatment and management of T2DM, exploring and systematizing the key effects of both umbilical cord MSC and its factor-rich secretome accordingly with the major complications associated to T2DM.

Título: Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach

Revista: Cell & Tissue Research

JCR: 5.248 (2020)

Referência Bibliográfica: Gomes, A., Coelho, P., Soares, R., & Costa, R. (2021). Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach. Cell and Tissue Research, 385(3), 497-518. https://doi.org/10.1007/s00441-021-03461-4

 

 

Obesity is a risk factor for malignant melanoma. The lungs are main target organs for metastization and their immune response is a key modulator of this mechanism. The concept that the metastatic potential of some types of cancer is reduced or inhibited by obesity, known as the obesity paradox, drives major concerns on the prognosis of metastasized patients. The aim of this study was to investigate how high-fat diet (HFD)-induced obesity affects melanoma metastization. C57Bl6/J mice were fed with HFD or standard diet for 180 days and inoculated intravenously with B16F10 melanoma cells. Upon 21 days of inoculation, lung tissue of overweight and lean mice was assessed for histology and immunohistochemistry assays. Adipokine antibody arrays were performed in mice serum. In vitro RAW 264.7 macrophage cultures were established and incubated with FGF-21 and/or lipopolysaccharide (LPS). Conditioned media was added to B16F10 cells for viability quantification. HFD-fed mice presented a reduced number of metastases with lower proliferative rates. The high content of inflammatory foci observed in noninoculated obese mice was significantly decreased upon B16F10 inoculation, concurrent with a slight fibrosis reduction. Plasma levels of fibroblast growth factor-21 (FGF-21), an endocrine regulator, were elevated in noninoculated HFD mice and the expression of FGF receptor 1 (FGFR-1) was significantly upregulated after inoculation. FGF-21 reduced melanoma viability in LPS-stimulated macrophages. Altogether, these findings suggest that higher amounts of FGF-21 are able to counterbalance the proinflammatory effects associated with obesity, protecting the lungs from melanoma metastization.

Título: Lower melanoma pulmonary metastatic burden in obese mice: role of FGF-21

Revista: Melanoma Research

JCR: 3.599 (2020)

Referência Bibliográfica: Fonseca, M., Soares, R., & Coelho, P. (2021). Lower melanoma pulmonary metastatic burden in obese mice: role of FGF-21. Melanoma Research, 31(6), 515-525. https://doi.org/10.1097/cmr.0000000000000781

 

This work addresses the development of a disposable electrochemical genosensor for the detection of the toxic dinoflagellate, Alexandrium minutum. Analyzing public databases, a specific 70 bp DNA probe, targeting A. minutum, was selected and designed. The genosensor methodology implied the immobilization of a A. minutum-specific DNA-capture probe onto screen-printed gold electrodes (SPGE). To improve both the selectivity and to avoid strong secondary structures, that could hinder the hybridization efficiency, a sandwich format of the A. minutum gene was designed using a fluorescein isothiocyanate-labelled signaling DNA robe and enzymatic amplification of the electrochemical signal. Using this electrochemical enosensor, a concentration range from 0.12 to 1.0 nM, a LD of 24.78 pM with a RSD <5.2% was determined. The genosensor was successfully applied to the selective analysis of the targeted A. minutum specific region denatured genomic DNA extracted from toxic dinoflagellates resent in the Atlantic Ocean.

Título: Electrochemical genosensor for the detection of Alexandrium minutum dinoflagellates

Revista: Talanta

JCR: 6.057 (2020)

Referência Bibliográfica: Morais, S. L., Barros, P., Santos, M., Delerue-Matos, C., Gomes, A. C., & Fátima Barroso, M. (2021). Electrochemical genosensor for the detection of Alexandrium minutum dinoflagellates. Talanta222, 121416.

 

 

Radiotherapy is a treatment option for the majority of malignancies. However, because melanoma is known to be radioresistant, the use of ionizing radiation as an adjuvant therapy in cutaneous melanoma patients is ineffective. Obesity has now been recognized as a risk factor for melanoma. High adiposity is generally associated with a more pro-oxidative status. Oxidative stress is a major player in radiation therapy and also a common link between obesity and cancer. Several adipocyte-released proteins are known to have a role in controlling cellular growth and pro-survival signaling. For that reason, we investigated the influence of 3T3-L1 mature adipocyte secretome in B16-F10 malignant melanocyte radiosensitivity. We evaluated B16-F10 cell survival and redox homeostasis when exposed to four daily doses of ionizing radiation (2 Gy per day) up to a total of 8 Gy in a medical linear accelerator. B16-F10 melanocytes exhibited slight alterations in survival, catalase activity, nitrative stress and total oxidant concentration after the first 2 Gy irradiation. The motility of the melanocytes was also delayed by ionizing radiation. Subsequent irradiations of the malignant melanocytes led to more prominent reductions in overall survival. Remarkably, 3T3-L1 adipocyte-secreted molecules were able to increase the viability and migration of melanocytes, as well as lessen the pro-oxidant burden induced by both the single and cumulative X-ray doses. In vitro adipocyte-released factors protected B16-F10 malignant melanocytes from both oxidative stress and loss of viability triggered by radiation, enhancing the radioresistant phenoyype of these cells with a concomitant activation of the AKT signaling pathway These results both help to elucidate how obesity influences melanoma radioresistance and support the usage of conventional medical linear accelerators as a valid model for the in vitro radiobiological study of tumor cell lines.

Título: Adipocyte Secretome Increases Radioresistance of Malignant Melanocytes by Improving Cell Survival and Decreasing Oxidative Status

Revista: Radiation Research

JCR: 2.530 (2017)

Referência Bibliográfica: Coelho, P., et al. (2017). "Adipocyte Secretome Increases Radioresistance of Malignant Melanocytes by Improving Cell Survival and Decreasing Oxidative Status." Radiation Research 187(5): 581-588.

 

Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.

Título: Quinoxaline, its derivatives and applications: A State of the Art review

Revista: European Journal of Medicinal Chemistry

JCR: 3.902 (2015)

Referência Bibliográfica: Pereira, J. A., et al. (2015). "Quinoxaline, its derivatives and applications: A State of the Art review." European Journal of Medicinal Chemistry 97: 664-672.

 

Hippocampal neurogenesis has been suggested as a downstream event of antidepressants (AD) mechanism of action and might explain the lag time between AD administration and the therapeutic effect. Despite the widespread use of AD in the context of Major Depressive Disorder (MDD) there are no reliable biomarkers of treatment response phenotypes, and a significant proportion of patients display Treatment Resistant Depression (TRD). Fas/FasL system is one of the best-known death-receptor mediated cell signaling systems and is recognized to regulate cell proliferation and tumor cell growth. Recently this pathway has been described to be involved in neurogenesis and neuroplasticity. Since FAS -670A>G and FASL -844T>C functional polymorphisms never been evaluated in the context of depression and antidepressant therapy, we genotyped FAS -670A>G and FASL -844T>C in a subset of 80 MDD patients to evaluate their role in antidepressant treatment response phenotypes. We found that the presence of FAS -670G allele was associated with antidepressant bad prognosis (relapse or TRD: OR=6.200; 95% CI: [1.875–20.499]; p=0.001), and we observed that patients carrying this allele have a higher risk to develop TRD (OR=10.895; 95% CI: [1.362–87.135]; p=0.008). Moreover, multivariate analysis adjusted to potentials confounders showed that patients carrying G allele have higher risk of early relapse (HR=3.827; 95% CI: [1.072–13.659]; p=0.039). FAS mRNA levels were down-regulated among G carriers, whose genotypes were more common in TRD patients. No association was found between FASL-844T>C genetic polymorphism and any treatment phenotypes. Small sample size. Patients used antidepressants with different mechanisms of action. To the best of our knowledge this is the first study to evaluate the role of FAS functional polymorphism in the outcome of antidepressant therapy. This preliminary report associates FAS -670A>G genetic polymorphism with Treatment Resistant Depression and with time to relapse. The current results may possibly be given to the recent recognized role of Fas in neurogenesis and/or neuroplasticity.

Título: FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression

Revista: Journal of Affective Disorers

JCR: 3.570 (2015)

Referência Bibliográfica: (Santos, Carvalho et al. 2015)Santos, M., et al. (2015). "FAS -670A>G genetic polymorphism Is associated with Treatment Resistant Depression." Journal of Affective Disorders 185: 164-169.

 

Despite the impressive innate physical abilities of horses, camels, greyhounds, or pigeons, doping agents might be administered to these animals to improve their performance. To control these illegal practices, anti-doping analytical methodologies have been developed. This review compiles the analytical methods that have been published for the detection of prohibited substances administered to animals involved in sports over 30 years. Relevant papers meeting the search criteria that discussed analytical methods aiming to detect and/or quantify doping substances in animal biological matrices published from 1990 to 2019 were considered. A total of 317 studies were included, of which 298 were related to horses, demonstrating significant advances toward the development of doping detection methods for equine sports. However, analytical methods for the detection of doping agents in sports involving other species are lacking. Due to enhanced accuracy and specificity, chromatographic analysis coupled to mass spectrometry detection is preferred over immunoassays. Regarding biological matrices, blood and urine remain the first choice, although alternative biological matrices, such as hair and feces, have been considered. With the increasing number and type of drugs used as doping agents, the analytes addressed in the published papers are diverse. It is very important to continue to detect and quantify these drugs, recognizing those that are most frequently used, in order to punish the abusers, protect animals' health, and ensure a healthier and genuine competition.

Título: Doping detection in animals: A review of analytical methodologies published from 1990 to 2019

JCR: 3.345 (2020)

Referência Bibliográfica: Moreira, F., Carmo, H., Guedes de Pinho, P., & Bastos, M. d. L. (2021). Doping detection in animals: A review of analytical methodologies published from 1990 to 2019. Drug Testing and Analysis, 13(3), 474-504.

 

Hearing loss is one of the most common chronic conditions in older adults. In audiology literature, several studies have examined the attitudes and behavior of people with hearing loss; however, not much is known about the manner in which society in general views and perceives hearing loss. This exploratory study was aimed at understanding the social representation of hearing loss (among the general public) in the countries of India, Iran, Portugal, and the UK. We also compared these social representations. The study involved a cross-sectional design, and participants were recruited using the snowball sampling method. A total of 404 people from four countries participated in the study. Data were collected using a free-association task where participants were asked to produce up to five words or phrases that came to mind while thinking about hearing loss. In addition, they were also asked to indicate if each word they presented had positive, neutral, or negative associations in their view. Data were analyzed using various qualitative and quantitative methods. The most frequently occurring categories were: assessment and management; causes of hearing loss; communication difficulties; disability; hearing ability or disability; hearing instruments; negative mental state; the attitudes of others; and sound and acoustics of the environment. Some categories were reported with similar frequency in most countries (eg, causes of hearing loss, communication difficulties, and negative mental state), whereas others differed among countries. Participants in India reported significantly more positive and fewer negative associations when compared to participants from Iran, Portugal, and the UK. However, there was no statistical difference among neutral responses reported among these countries. Also, more differences were noted among these countries than similarities. These findings provide useful insights into the public perception of hearing loss that may prove useful in public education and counseling.

Título: Social representation of “hearing loss”: crosscultural exploratory study in India, Iran, Portugal, and the UK

JCR: 2.133 (2015)

Referência Bibliográfica: Manchaiah V, Danermark B, Ahmadi T, Tomé D, Zhao F, Li Q, Krishna R, Germundsson P. Social representation of “hearing loss”: cross-cultural exploratory study in India, Iran, Portugal, and the UK. Clin Interv Aging. 2015;10:1857-1872

 

Prostate cancer (PCa) varies clinically from very indolent, not requiring therapeutic intervention, to highly aggressive, entailing radical treatment. Currently, stratification of PCa aggressiveness is mostly based on Gleason score, serum PSA and TNM stage, but outcome prediction in an individual basis is suboptimal. Thus, perfecting pre-therapeutic discrimination between indolent and aggressive PCa, avoiding overtreatment is a major challenge. Epithelial to mesenchymal transition (EMT) allows epithelial cells to acquire mesenchymal properties, constituting a critical step in tumor invasion and metastization. Thus, we hypothesized that EMT-related markers might allow for improved assessment of PCa aggressiveness. Using RealTime ready Custom Panel 384 assay, 93 EMT-related genes were assessed in normal prostate tissues (NPT, n=5), stage pT2a+b-PCa (n=5) and stage pT3b-PCa (n=5), from which CAMK2N1, CD44, KRT14, TGFβ3 and WNT5A genes emerged as the most significantly altered. Expression levels were then evaluated in a larger series (16 NPT and 94 PCa) of frozen tissues using quantitative RT-PCR. Globally, CAMK2N1, CD44 and WNT5A displayed higher expression levels at higher stages and less differentiated PCa. CAMK2N1 and WNT5A immunoexpression analysis disclosed significantly lower expression in NPT and increasing proportion of high-expression cases from pT2a+b to pT3b and metastatic PCa. Furthermore, higher CAMK2N1 and WNT5A transcript levels associated with shorter disease-free and disease-specific survival. In multivariable analysis, a trend for WNT5A expression levels to independently predict DFS was disclosed (p=0.056).  Globally, our findings suggest an association between PCa aggressiveness and increased expression of CAMK2N1 and WNT5A, reflecting the acquisition of effective EMT characteristics by PCa cells.

Título: Expression of EMT-Related Genes CAMK2N1 and WNT5A is increased in Locally Invasive and Metastatic Prostate Cancer

Revista: Journal of Cancer

JCR: 4.207 (2019)

Referência Bibliográfica: Carneiro, I., Quintela-Vieira, F., Lobo, J., Moreira-Barbosa, C., Menezes, F. D., Martins, A. T., Oliveira, J., Silva, R., Jerónimo, C., & Henrique, R. (2019). Expression of EMT-Related Genes CAMK2N1 and WNT5A is increased in Locally Invasive and Metastatic Prostate Cancer. Journal of Cancer10(24), 5915–5925. https://doi.org/10.7150/jca.34564

 

Abdominal adiposity is a cardiovascular risk factor; it is assumed that the combination of radiofrequency and physical exercise may decrease this excess of adipose tissue. To understand whether an aerobic physical exercise session associated with abdominal radiofrequency increases the level of lipolytic activity. The study analyzes the effect of a combined aerobic exercise session with radiofrequency. Participants were 30 healthy female volunteers, aged 18-28 years, randomly assigned to an experimental group and placebo group. They were characterized by a sociodemographic questionnaire, the International Physical Activity Questionnaire and the Food Frequency Questionnaire. The groups performed an abdominal radiofrequency session followed by moderate aerobic exercise, assessing glycerol concentration and lipid profile values before and after the intervention. In the experimental group, a percentage of potency was used that allowed to maintain the temperature between 40º C and 42º C to the epidermis. In the placebo group, the power of the radiofrequency was 0 Watt. To compare results, Student's t test was used for a significance level of 0.05. There were no significant changes in glycerol concentrations between groups (P > 0.05). There were no changes in the lipid profile of both groups after the intervention (P > 0.05). The association of exercise with radiofrequency did not present an increased effect on lipolytic activity when compared to the isolated exercise. The application of this technique is a safe intervention.

Título: Effect of an aerobic exercise session combined with abdominal radiofrequency on lipolytic activity in women: Randomized control trial

Revista: Journal of Cosmetic Dermatology

JCR: 2.696 (2019)

Referência Bibliográfica: Noites, A., et al. (2020). "Effect of an aerobic exercise session combined with abdominal radiofrequency on lipolytic activity in women: Randomized control trial." Journal of Cosmetic Dermatology 19(3): 638-645.

  

Cinnamic acids are compounds of natural origin that can be found in many different parts of a wide panoply of plants, where they play the most diverse biological roles, often in a conjugated form. For a long time, this has been driving Medicinal Chemists towards the investigation of the therapeutic potential of natural, semi-synthetic, or fully synthetic cinnamic acid conjugates. These efforts have been steadily disclosing promising drug leads, but a wide chemical space remains that deserves to be further explored. Amongst different reported approaches, the combination or conjugation of cinnamic acids with known drugs has been addressed in an attempt to produce either synergistic or multi-target action. In this connection, the present review will focus on efforts of the past decade regarding conjugation with cinnamic acids as a tool for the rescuing or the repurposing of classical antimalarial drugs, and also on future perspectives in this particular field of research. 

Título: Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs

Revista: Molecules

JCR: 4.412 (2020)

Referência Bibliográfica: Silva, A. T., et al. (2020). "Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs." Molecules 25(1): 66.

 

Polycyclic aromatic hydrocarbons (PAHs) are a class of organic compounds commonly found as soil contaminants. Fungal degradation is considered as an environmentally friendly and cost-effective approach to remove PAHs from soil. Acenaphthylene (Ace) and Benzo[a]anthracene (BaA) are two PAHs that can coexist in soils; however, the influence of the presence of each other on their biodegradation has not been studied. The biodegradation of Ace and BaA, alone and in mixtures, by the white rot fungus Pleurotus ostreatus was studied in a sandy soil.

Título: Influence of mixtures of acenaphthylene and benzo[a]anthracene on their degradation by Pleurotus ostreatus in sandy soil

Revista: Journal of Soils and Sediments

JCR: 2.107 (2013)

Referência Bibliográfica: Rocha, I., Pinto, E., Ferreira, I.M.P.L.V.O. et al. Influence of mixtures of acenaphthylene and benzo[a]anthracene on their degradation by Pleurotus ostreatus in sandy soil. J Soils Sediments 14, 829–834 (2014). https://doi.org/10.1007/s11368-013-0804-1

 

To characterize 2-year changes occurring in neurodegeneration, edema, and capillary dropout in nonproliferative diabetic retinopathy. Two-year prospective longitudinal observational cohort of eyes/patients with type 2 diabetes using spectral domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA). Eyes were examined three times with intervals of 1 year. Thickness of the full retina and layer-by-layer measurements were used to identify edema or neurodegeneration. OCTA vessel density maps of the retina were used to identify capillary dropout. Early Treatment Diabetic Retinopathy Study (ETDRS) classification was performed using the seven-field ETDRS protocol. A total of 62 eyes from 62 patients with diabetes were followed for 2 years. After verification for image quality, a total of 44 eyes from 44 patients (30% women) aged 52 to 80 years were retained for data analysis. There were 18 eyes with ETDRS grades 10 to 20, 17 eyes with ETDRS grade 35, and 9 eyes with ETDRS grades 43 to 47. During the 2-year follow-up period, there was a progressive increase in capillary dropout, whereas edema and neurodegeneration remained stable. In multivariate analysis, considering a model adjusted for age, sex, hemoglobin A1C, visual acuity, and diabetes duration, vessel density remained significantly different between Diabetic Retinopathy Severity Scale groups (Wilks’ λ = 0.707; P = 0.015) showing association with disease progression. Capillary dropout increased in a period of 2 years in eyes with minimal, mild, and moderate diabetic retinopathy, whereas the presence of edema and neurodegeneration remained stable.

Título: Characterization of Disease Progression in the Initial Stages of Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study

Revista: Investigative Ophthalmology & Visual Science

JCR: 4.799

Referência Bibliográfica: Marques, I. P., et al. (2020). "Characterization of Disease Progression in the Initial Stages of Retinopathy in Type 2 Diabetes: A 2-Year Longitudinal Study." Investigative Ophthalmology & Visual Science 61(3): 20-20.

 

Health and fitness apps have potential benefits to improve self-management and disease control among patients with asthma. However, inconsistent use rates have been reported across studies, regions, and health systems. A better understanding of the characteristics of users and nonusers is critical to design solutions that are effectively integrated in patients’ daily lives, and to ensure that these equitably reach out to different groups of patients, thus improving rather than entrenching health inequities.

Título: Determinants of the Use of Health and Fitness Mobile Apps by Patients With Asthma: Secondary Analysis of Observational Studies

Revista: Journal of Medical Internet Research

JCR: 5.428

Referência Bibliográfica: Neves, A. L., et al. (2021). "Determinants of the Use of Health and Fitness Mobile Apps by Patients With Asthma: Secondary Analysis of Observational Studies." J Med Internet Res 23(9): e25472.

 

Three years of study showed that female and male vocational dancers displayed lower bone mass compared to controls, at forearm, lumbar spine and femoral neck. Energy intake was found to positively predict bone mass accruals only in female dancers at femoral neck. Vocational dancers can be a risk population to develop osteoporosis.

Título: Associations between nutrition, energy expenditure and energy availability with bone mass acquisition in dance students: a 3-year longitudinal study

Revista: Archives of Osteoporosis

JCR: 2.617

Referência Bibliográfica: Amorim, T., et al. (2021). "Associations between nutrition, energy expenditure and energy availability with bone mass acquisition in dance students: a 3-year longitudinal study." Archives of Osteoporosis 16(1): 141.

 

Tipo: Póster

Título: Exercise addiction, body dysmorphic disorder, and use of enhancement drugs during the COVID-19 pandemic confinement period: A transcultural study

Revista: European Psychiatry

JCR: 5.361

Referência Bibliográfica: Dores, A., Carvalho, I., Burkauskas, J., Beretta, V., Ioannidis, K., Simonato, P., . . . Corazza, O. (2021). Exercise addiction, body dysmorphic disorder, and use of enhancement drugs during the COVID-19 pandemic confinement period: A transcultural study. European Psychiatry, 64(S1), S290-S291. doi:10.1192/j.eurpsy.2021.779

 

Tipo: Póster

Título: Web-based tools applied to therapy and counseling during the COVID-19 pandemic

Revista: European Psychiatry

JCR: 5.361

Referência Bibliográfica: Dores, A. R., Geraldo, A., Carvalho, I., & Barbosa, F. (2021). Web-based tools applied to therapy and counseling during the COVID-19 pandemic. European Psychiatry, 64(S1), S293-S293. https://doi.org/10.1192/j.eurpsy.2021.786

 

The exposure of both crop fields and humans to antibiotic-resistant bacteria in animal excreta is an emergent concern of the One Health initiative. This study assessed the contamination of livestock manure from poultry, pig, dairy farms and slaughterhouses in Portugal with resistance determinants. The resistance profiles of 331 Enterobacteriaceae isolates to eight β-lactam (amoxicillin, cefoxitin, cefotaxime, cefpirome, aztreonam, ceftazidime, imipenem and meropenem) and to five non-β-lactam antibiotics (tetracycline (TET), trimethoprim/sulfamethoxazole (SXT), ciprofloxacin (CIP), chloramphenicol (CHL) and gentamicin) was investigated. Forty-nine integron and non-β-lactam resistance genes were also screened for. Rates of resistance to the 13 antibiotics ranged from 80.8% to 0.6%. Multidrug resistance (MDR) rates were highest in pig farm samples (79%). Thirty different integron and resistance genes were identified. These were mainly associated with resistance to CHL (catI and catII), CIP (mainly, qnrS, qnrB and oqx), TET (mainly tet(A) and tet(M)) and SXT (mostly dfrIa group and sul3). In MDR isolates, integron presence and non-β-lactam resistance to TET, SXT and CHL were positively correlated. Overall, a high prevalence of MDR Enterobacteriaceae was found in livestock manure. The high gene diversity for antibiotic resistance identified in this study highlights the risk of MDR spread within the environment through manure use.

Título: Prevalence of Antibiotic Resistance Genes in Multidrug-Resistant Enterobacteriaceae on Portuguese Livestock Manure

Revista: Antibiotics

JCR:  3.893

Referência Bibliográfica: 

Amador, P., et al. (2019). "Prevalence of Antibiotic Resistance Genes in Multidrug-Resistant Enterobacteriaceae on Portuguese Livestock Manure." Antibiotics 8(1): 23.

 

We report on an architecture of a multi-purpose trigger system based on inexpensive and off-the-shelf modules, with logic implemented in three levels, that can be used in a variety of small/medium systems just by writing a few registers using the accompanying software. The developed trigger algorithms are described in Very High Speed Integrated Circuits (VHSIC) Hardware Description Language (VHDL) and implemented using a Xilinx XC6LX45-2 FPGA. In its present implementation, for the sake of simplicity, communication with the external world is done using the Serial Peripheral Interface (SPI), which allows easy connection to a Raspberry Pi2 running Linux. The Raspberry software was written in C++ and enables configuring and checking of the underlying FPGA and retrieving the monitoring data. The system has been used, with success, in several applications, from lab setup to industrial and pre-clinical environments showing its versatility and robustness.

Título: Multi-purpose trigger system for medium particle detector devices

Revista: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JCR: 1.265

Referência Bibliográfica: Clemêncio, F., et al. (2019). "Multi-purpose trigger system for medium particle detector devices." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 929: 142-147.

 

Tipo: Póster

Título: The SHiP timing detector based on MRPC

Revista: Journal of Instrumentation

JCR: 1.415

Referência Bibliográfica: Blanco, A., et al. (2020). "The SHiP timing detector based on MRPC." Journal of Instrumentation 15(10): C10017-C10017.

 

Lack of knowledge about iodine has been suggested as a risk factor for iodine deficiency in pregnant women, but no studies have addressed this issue in Portugal. So, the aim of this study was to investigate iodine knowledge among Portuguese pregnant women and its association with iodine status. IoMum, a prospective observational study, included 485 pregnant women recruited at Centro Hospitalar e Universitário de S. João, Porto, between the 10th and 13th gestational weeks. Partial scores for knowledge on iodine importance, on iodine food sources or on iodised salt were obtained through the application of a structured questionnaire. Then, a total iodine knowledge score was calculated and grouped into low, medium and high knowledge categories. Urinary iodine concentration (UIC) was measured in spot urine samples by inductively coupled plasma MS. Of the pregnant women, 54 % correctly recognised iodine as important to neurocognitive development, 32 % were unable to identify any iodine-rich food and 71 % presented lack of knowledge regarding iodised salt. Of the women, 61 % had a medium total score of iodine knowledge. Knowledge on iodine importance during pregnancy was positively associated with iodine supplementation and also with UIC. Nevertheless, median UIC in women who correctly recognised the importance of iodine was below the cut-off for adequacy in pregnancy (150 µg/l). In conclusion, knowledge on iodine importance is positively associated with iodine status. Despite this, recognising iodine importance during pregnancy may not be sufficient to ensure iodine adequacy. Literacy-promoting actions are urgently needed to improve iodine status in pregnancy.

Tìtulo: Iodine knowledge is associated with iodine status in Portuguese pregnant women: results from the IoMum cohort study

Revista: British Journal of Nutrition

JCR: 3.718

Referência Bibliográfica: Pinheiro, C., Xavier Moreira, N., Ferreira, P., Matta Coelho, C., Guimarães, J., Pereira, G., Cortez, A., Bracchi, I., Pestana, D., Barreiros Mota, I., Prucha, C., Martins, C., Alves Ribeiro, C., Pinto, E., Almeida, A., Delerue-Matos, C., Montenegro, N., Dias, C. C., Moreira-Rosário, A., ... Keating, E. (Accepted/In press). Iodine knowledge is associated with iodine status in Portuguese pregnant women: Results from the IoMum cohort study. British Journal Of Nutrition. https://doi.org/10.1017/S0007114521000155

 

Mental health and active aging are two of the main concerns in the 21st century. To search for new neuroprotective compounds, extracts of Codium tomentosum Stackhouse and Fucus vesiculosus L. were obtained through multi-step (four step) subcritical water extraction using a temperature gradient. The safety assessment of the extracts was performed by screening pharmaceutical compounds and pesticides by UHPLC-MS/MS, and iodine and arsenic levels by ICP-MS. Although the extracts were free of pharmaceutical compounds and pesticides, the presence of arsenic and high iodine contents were found in the first two extraction steps. Thus, the health-benefits were only evaluated for the fractions obtained in steps 3 and 4 from the extraction process. These fractions were tested against five brain enzymes implicated in Alzheimer’s, Parkinson’s, and major depression etiology as well as against reactive oxygen and nitrogen species, having been observed a strong enzyme inhibition and radical scavenging activities for the step 4 fractions from both seaweed species. Regarding the variation of the chemical composition during the extraction, step 1 fractions were the richest in phenolic compounds. With the increase in temperature, Maillard reaction, caramelization and thermo-oxidation occurred, and the resulting products positively affected the antioxidant capacity and the neuroprotective effects.

Título: Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety

Revista: Processes

JCR: 2.847

Referência Bibliográfica: Soares, C., et al. (2021). "Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety." Processes 9(5): 893.

 

There are many controversies regarding the relationship between lead exposure andcomplications in pregnancy. Preeclampsia (PE) is a maternal hypertensive disorder which is one of the main causes of maternal and foetal mortality. The aim of our study was to assess blood lead level (BLL) in Polish women with PE (PE group, n = 66) compared with healthy, non-pregnant women (CNP group, n = 40) and healthy pregnant women (CP group, n = 40). BLL was determined by inductively coupled plasma mass spectrometry (ICP-MS). The systolic blood pressure (SBP), diastolic blood pressure (DBP) and BLL in the CP group were significantly lower than in the PE group (p < 0.001). Logistic regression analyses of BLL showed a significant positive relationship with the presence of PE. Furthermore, both the SBP and DBP values were positively associated with BLL. This study indicates that preeclamptic women tend to present with significantly higher BLL compared to healthy pregnant women. There were no differences in the BLL between the CP and CNP groups.

Título: Lead Levels in Non-Occupationally Exposed Women with Preeclampsia

Revista: Molecules

JCR: 4.411

Referência Bibliográfica: Gajewska, K., et al. (2021). "Lead Levels in Non-Occupationally Exposed Women with Preeclampsia." Molecules 26(10): 3051.

 

The capacity of skimmed milk to neutralise increased reactive oxygen species (ROS) and to attenuate nitric oxide (NO) production, as well as to present cytoprotective effect at the intestinal level was assessed after in vitro gastro-intestinal digestion. The impact on ROS modulation was evaluated at a non-cytotoxic concentration of hydrogen peroxide (H2O2) in a co-culture of Caco-2 and HT-29 intestinal cells. In parallel, a cytotoxic concentration of H2O2 was used to study the effect of digested milk against induced cell apoptosis. Concerning induced NO production, it was evaluated using the model lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Results showed that digested milk prevented the increase of basal ROS level in the intestinal epithelium and attenuated NO production by LPS-stimulated macrophage cells. In the H2O2-induced cytotoxicity assay, digested milk had no protection against apoptosis, confirmed by the failure in attenuating activated caspase-3/7.

Título: Effect of skimmed milk on intestinal tract: Prevention of increased reactive oxygen species and nitric oxide formation

Revista: International Dairy Journal

JCR: 3.032

Referência Bibliográfica: Pinho, S. C. M., et al. (2021). "Effect of skimmed milk on intestinal tract: Prevention of increased reactive oxygen species and nitric oxide formation." International Dairy Journal 118: 105046.

 

Given the widespread use of glyphosate (GLY), this agrochemical is becoming a source of contamination in agricultural soils, affecting non-target plants. Therefore, sustainable strategies to increase crop tolerance to GLY are needed. From this perspective and recalling silicon (Si)’s role in alleviating different abiotic stresses, the main goal of this study was to assess if the foliar application of Si, either as bulk or nano forms, is capable of enhancing Solanum lycopersicum L. tolerance to GLY (10 mg kg−1). After 28 day(s), GLY-treated plants exhibited growth-related disorders in both shoots and roots, accompanied by an overproduction of superoxide anion (O2•−) and malondialdehyde (MDA) in shoots. Although plants solely exposed to GLY have activated non-enzymatic antioxidant mechanisms (proline, ascorbate and glutathione), a generalized inhibition of the antioxidant enzymes was found, suggesting the occurrence of great redox disturbances. In response to Si or nano-SiO2 co-application, most of GLY phytotoxic effects on growth were prevented, accompanied with a better ROS removal, especially by an upregulation of the main antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX). Overall, results pointed towards the potential of both sources of Si to reduce GLY-induced oxidative stress, without major differences between their efficacy.

Título: Silicon Improves the Redox Homeostasis to Alleviate Glyphosate Toxicity in Tomato Plants—Are Nanomaterials Relevant?

Revista: Antioxidants

JCR: 6.312

Referência Bibliográfica: Soares, C., et al. (2021). "Silicon Improves the Redox Homeostasis to Alleviate Glyphosate Toxicity in Tomato Plants—Are Nanomaterials Relevant?" Antioxidants 10(8): 1320.

 

Strategies to minimize the effects of glyphosate (GLY), the most used herbicide worldwide, on non-target plants need to be developed. In this context, the current study was designed to evaluate the potential of nitric oxide (NO), provided as 200 µM sodium nitroprusside (SNP), to ameliorate GLY (10 mg kg−1 soil) phytotoxicity in tomato plants. Upon herbicide exposure, plant development was majorly inhibited in shoots and roots, followed by a decrease in flowering and fruit set; however, the co-application of NO partially prevented these symptoms, improving plant growth. Concerning redox homeostasis, lipid peroxidation (LP) and reactive oxygen species (ROS) levels rose in response to GLY in shoots of tomato plants, but not in roots. Additionally, GLY induced the overaccumulation of proline and glutathione, and altered ascorbate redox state, but resulted in the inhibition of the antioxidant enzymes. Upon co-treatment with NO, the non-enzymatic antioxidants were not particularly changed, but an upregulation of all antioxidant enzymes was found, which helped to keep ROS and LP under control. Overall, data point towards the benefits of NO against GLY in tomato plants by reducing the oxidative damage and stimulating detoxification pathways, while also preventing GLY-induced impairment of flowering and fruit fresh mass.

Título: Foliar Application of Sodium Nitroprusside Boosts Solanum lycopersicum L. Tolerance to Glyphosate by Preventing Redox Disorders and Stimulating Herbicide Detoxification Pathways

Revista: Plants

JCR: 3.935

Referência Bibliográfica: Soares, C., et al. (2021). "Foliar Application of Sodium Nitroprusside Boosts Solanum lycopersicum L. Tolerance to Glyphosate by Preventing Redox Disorders and Stimulating Herbicide Detoxification Pathways." Plants 10(9): 1862.

 

Age-related neurodegenerative disorders, like Alzheimer’s or Parkinson’s disease, are becoming a major issue to public health care. Currently, there is no effective pharmacological treatment to address cognitive impairment in these patients. Here, we aim to explore the role of exercise-induced trophic factor enhancement in the prevention or delay of cognitive decline in patients with neurodegenerative diseases.

Título: Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic facts

Revista: Expert Review of Neurotherapeutics

JCR: 3.149

Referência Bibliográfica: Carlos Campos, Nuno Barbosa F. Rocha, Eduardo Lattari, Flávia Paes, António E. Nardi & Sérgio Machado (2016): Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors, Expert Review of Neurotherapeutics, DOI: 10.1080/14737175.2016.1179582

 

Evidence indicates that exposure to high levels of noise adversely affects human health, and these effects are dependent upon various factors. In hospitals, there are many sources of noise, and high levels exert an impact on patients and staff, increasing both recovery time and stress, respectively. The goal of this pilot study was to develop, implement, and evaluate the effectiveness of a training program (TP) on noise reduction in a neonatal intensive care unit (NICU) by comparing the noise levels before and after the implementation of the program. In total, 79 health professionals participated in the study. The measurements of sound pressure levels took into account the layout of the unit and locations of the main sources of noise.

Título: Is There Sufficient Training of Health Care Staff on Noise Reduction in Neonatal Intensive Care Units? a Pilot Study From Neonoise Project

Revista: Journal of Toxicology and Environmental Health

JCR: 2.731

Referência Bibliográfica: Carvalhais, C., Santos, J., da Silva, M. V., & Xavier, A. (2015). Is There Sufficient Training of Health Care Staff on Noise Reduction in Neonatal Intensive Care Units? a Pilot Study From Neonoise Project. Journal of Toxicology and Environmental Health, Part A, 78(13-14), 897-903. https://doi.org/10.1080/15287394.2015.1051204

 

People with severe mental illness (SMI), schizophrenia in particular, show considerable functional impairment in emotional recognition and social perception, which negatively affects interpersonal relationships and social functioning. Owing to its ecological validity, virtual reality (VR) has been observed to improve both assessment and training of emotional recognition skills of people with SMI. This article includes two studies: (a) a descriptive study on the Virtual Reality program for Facial Emotion Recognition (VR-FER) and (b) an empirical study that presents the results of the application of the VR-FER’s first module. For the second study, data were collected using two samples: a group of 12 people with schizophrenia and a reference group of 12 people who were mentally healthy. Data analysis comprised descriptive (mean, standard deviation) and inferential statistics (Mann–Whitney U test). Results showed that the first group presented a lower number of correct answers and a higher number of incorrect answers compared with the second group regarding facial emotion recognition (FER), thereby confirming the need to develop strategies to improve emotional recognition and social perception in people with schizophrenia. VR-FER is regarded a strategic training program for FER, using latest technology and following rehabilitation guidelines for SMI.

Título: Facial emotion recognition: virtual reality program for facial emotion recognition—A trial program targeted at individuals with Schizophrenia

Revista: Rehabilitation Counseling Bulleting

JCR: 1.136

Referência Bibliográfica: Souto, T., Silva, H., Leite, A., Baptista, A., Queirós, C., & Marques, A. (2019). Facial Emotion Recognition: Virtual Reality Program for Facial Emotion Recognition—A Trial Program Targeted at Individuals With Schizophrenia. Rehabilitation Counseling Bulletin, 63(2), 79-90. https://doi.org/10.1177/0034355219847284

 

Os défices neurocognitivos na Esquizofrenia constituem uma das suas mais marcantes características. Investigações recentes têm procurado estabelecer uma relação causal entre os défices neurocognitivos na Esquizofrenia e a resposta funcional. Os estudos até agora realizados, sobretudo os que se centraram no estudo da qualidade de vida, têm evidenciado tantas associações claras, como associações pouco robustas, ou até mesmo inexistentes. Assim, este estudo teve como objectivo identificar os constructos neurocognitivos que se apresentam de modo diferencial como preditores de dimensões específicas da qualidade de vida. A amostra final foi constituída por 37 participantes com Esquizofrenia. Todos os participantes foram avaliados com uma bateria de testes neurocognitivos. A avaliação da qualidade de vida foi realizada através da versão portuguesa do WHOQOL-Bref. Foram realizadas análises correlacionais entre todos os factores neurocognitivos e os diferentes domínios de qualidade de vida e análises de regressão com recurso ao método stepwise para obter os modelos preditores. Os resultados evidenciaram a existência de correlações significativas entre a maior parte dos constructos neurocognitivos e a qualidade de vida. Os modelos preditores encontrados explicam entre 21% e 49% da variância nos domínios de qualidade de vida considerados, tendo sido identificados os seguintes preditores neurocognitivos: para o Domínio Físico, as funções executivas; para os domínios Psicológico e Relações Sociais, a atenção e a organização visuo-espacial; para o domínio Ambiente, a atenção e a função executiva. Estes resultados sugerem a importância das funções neurocognitivas básicas (relacionadas com a capacidade de responder adaptativamente às mudanças e ao feedback ambiental, com a aptidão de manter o foco de atenção e com a aptidão de organizar correctamente os elementos perceptivos), para a determinação da qualidade de vida das pessoas com Esquizofrenia.

Título: Relação entre neurocognição e qualidade de vida em pessoas com esquizofrenia

Revista: Acta Médica Portuguesa

JCR: 0.256

Referência Bibliográfica: Rocha, N., Queirós, C., Aguiar, S., Marques, A., & Horta, M. P. (2009). Relação entre a neurocognição e qualidade de vida em pessoas com esquizofrenia. Acta Médica Portuguesa

 

This study aims to explore the use of force vs. time data obtained from an isometric handgrip test to match a frailty state based on the TFI score. BodyGrip, a novel prototype system, is used for handgrip strength over 10 s time interval tests. A cross-sectional study with a non-probabilistic sample of community-dwelling elderly women was conducted. The force/time data collected from the dominant handgrip strength test, together with the Tilburg Frailty Indicator (TFI) test results, were used to train artificial neural networks. Different models were tested, and the frailty matching of TFI scores reached a minimum accuracy of 75%. Despite the small sample size, the BodyGrip system appears to be a promising tool for exploring new frailty-related features. The adopted strategy foresees ultimately configuring the system to be used as an expedite mode for identifying individuals at risk, allowing an easy, quick, and frequent person-centered care approach. Additionally, it is suitable for following up of the elderly in particular, and it may assume a relevant role in the mitigation of the increase in frailty evolution during and after the imposed isolation of the COVID-19 pandemic. Further use of the system will improve the robustness of the artificial neural network algorithm.

Título: Handgrip Strength Time Profile and Frailty: An Exploratory Study

Revista: Applied Sciences

JCR (2019): 2.679

Referência Bibliográfica: Urbano, D., Restivo, M. T., Barbosa, M. R., Fernandes, Â., Abreu, P., Chousal, M. D., & Coelho, T. (2021). Handgrip Strength Time Profile and Frailty: An Exploratory Study. Applied Sciences, 11(11). https://doi.org/10.3390/app11115134

 

Título: Validation of App and Phone Versions of the Control of Allergic Rhinitis and Asthma Test (CARAT)

Revista: Journal of investigational allergology and clinical immunology

JCR (2019): 5.172

Referência Bibliográfica: Jácome C, Pereira R, Almeida R, Amaral R, Correia MA, Mendes S, Vieira-Marques P, Ferreira JA, Lopes I, Gomes J, Vidal C, López Freire S, Méndez Brea P, Arrobas A, Valério M, Chaves Loureiro C, Santos LM, Couto M, Araujo L, Todo Bom A, Azevedo JP, Cardoso J, Emiliano M, Gerardo R, Lozoya C, Pinto PL, Castro Neves A, Pinto N, Palhinha A, Teixeira F, Ferreira-Magalhães M, Alves C, Coelho D, Santos N, Menezes F, Gomes R, Cidrais Rodrigues JC, Oliveira G, Carvalho J, Rodrigues Alves R, Moreira AS, Costa A, Abreu C, Silva R, Morête A, Falcão H, Marques ML, Câmara R, Cálix MJ, Bordalo D, Silva D, Vasconcelos MJ, Fernandes RM, Ferreira R, Freitas P, Lopes F, Almeida Fonseca J; INSPIRERS group. Validation of App and Phone Versions of the Control of Allergic Rhinitis and Asthma Test (CARAT). J Investig Allergol Clin Immunol. 2021 Jun 22;31(3):270-273. doi: 10.18176/jiaci.0640. Epub 2020 Aug 26. PMID: 32856596.

 

The Designated Medical Event (DME) is a serious medical event that isoften causally associated with medicines. This way, EMA has developed a list of DME,through Medical Dictionary for Regulatory Activities (MedDRA). The list is used bythe EMA and Member States to focus on suspected adverse drug reaction(ADR) re-ports that deserve special attention, irrespective of statistical criteria used to pri-oritise safety reviews. DME search in ADR reports is one of the methods used todetect safety signals. The objective of our study is to identify and characterize thereports of ADR that contain the DME, in Portugal.Methods:A retrospective studywas conducted to identify and characterize the spontaneous ADR reports with DME,occurred in Portugal, between 2014 to 2019. A descriptive analysis was performed forthe following data: type of notifier (consumer or healthcare professional), medicinesclassified by the Anatomical Therapeutic Chemical Code, ADR coded with MedDRAand description of ADR in the summary of product characteristics (SmPC).Results:During this 5-year period, the Portuguese Pharmacovigilance Systemreceived 15344 reports, of these 1335 correspond to reports with DME (1305 byhealthcare professionals; 30 by consumers). The annual percentage of reports withDME has been increasing, with the exception of the last year. The most frequent ATCgroup with or without DME is“Antiinfectives For Systemic Use”. The most frequentSystem Organ Classes of the reports with the DME is“Skin and subcutaneous tissuedisorders”. Of the 1335 reports with DME terms, 130 of these reports are notdescribed in the SmPC.Conclusions:It is important to obtain real-word data,especially in the area of drug safety, because it is a way to prevent ADR. In this way,notifiers should be made aware of the importance of sharing data related to ADR,thus increasing knowledge about the safety profile of medicines.

Título: Real-World DATA of ADR Reports in Signal Detection - DME Perspective

Revista: Value in Health

JCR (2019): 5.725

Referência Bibliográfica: Marques Rodrigues, N., & Silva, A. (2021). PNS22 Real-World DATA of ADR Reports in Signal Detection - DME Perspective. Value in Health, 24, S176. https://doi.org/10.1016/j.jval.2021.04.877

 

The interactivity of an immersive environment comes up from the relationship that is established between the user and the system. This relationship results in a set of data exchanges between human and technological actors. The real-time biofeedback devices allow to collect in real time the biodata generated by the user during the exhibition. The analysis, processing and conversion of these biodata into multimodal data allows to relate the stimuli with the emotions they trigger. This work describes an adaptive model for biofeedback data flows management used in the design of interactive immersive systems. The use of an affective algorithm allows to identify the types of emotions felt by the user and the respective intensities. The mapping between stimuli and emotions creates a set of biodata that can be used as elements of interaction that will readjust the stimuli generated by the system. The real-time interaction generated by the evolution of the user’s emotional state and the stimuli generated by the system allows him to adapt attitudes and behaviors to the situations he faces.

Título: Adaptive Model for Biofeedback Data Flows Management in the Design of Interactive Immersive Environments

Revista: Applied Sciences

JCR (2019): 2.679

Referência Bibliográfica: Gomes, P. V., Marques, A., Donga, J., Sá, C., Correia, A., & Pereira, J. (2021). Adaptive Model for Biofeedback Data Flows Management in the Design of Interactive Immersive Environments. Applied Sciences, 11(11). https://doi.org/10.3390/app11115067 

 

To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. Results: A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.

Título: Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study

Revista: Journal of Clinical Medicine

JCR (2019): 4.241

Referência Bibliográfica: Marques, I. P., Kubach, S., Santos, T., Mendes, L., Madeira, M. H., de Sisternes, L., Tavares, D., Santos, A. R., Lewis, W., Lobo, C., Durbin, M. K., & Cunha-Vaz, J. (2021). Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study. Journal of Clinical Medicine, 10(11). https://doi.org/10.3390/jcm10112296  

 

Arsenic (As), mercury (Hg), and copper (Cu) are among the major historical and contemporary metal pollutants linked to global anthropogenic activities. Enterococcus have been considered indicators of fecal pollution and antibiotic resistance for years, but its largely underexplored metallome precludes understanding their role as metal pollution bioindicators as well. Our goal was to determine the occurrence, diversity, and phenotypes associated with known acquired genes/operons conferring tolerance to As, Hg or Cu among Enterococcus and to identify their genetic context (381 field isolates from diverse epidemiological and genetic backgrounds; 3547 enterococcal genomes available in databases representing a time span during 1900–2019). Genes conferring tolerance to As (arsA), Hg (merA) or Cu (tcrB) were used as biomarkers of widespread metal tolerance operons. Different variants of metal tolerance (MeT) genes (13 arsA, 6 merA, 1 tcrB) were more commonly recovered from the food-chain (arsAtcrB) or humans (merA), and were shared with 49 other bacterial taxa. Comparative genomics analysis revealed that MeT genes occurred in heterogeneous operons, at least since the 1900s, with an increasing accretion of antibiotic resistance genes since the 1960's, reflecting diverse antimicrobial pollution. Multiple MeT genes were co-located on the chromosome or conjugative plasmids flanked by elements with high potential for recombination, often along with antibiotic resistance genes. Phenotypic analysis of some isolates carrying MeT genes revealed up to 128× fold increase in the minimum inhibitory concentrations to metals. The main distribution of functional MeT genes among Enterococcus faecium and Enterococcus faecalis from different sources, time spans, and clonal lineages, and their ability to acquire diverse genes from multiple taxa bacterial communities places these species as good candidates to be used as model organisms in future projects aiming at the identification and quantification of bioindicators of metal polluted environments by anthropogenic activities.

Título: Diversity of metal and antibiotic resistance genes in Enterococcus spp. from the last century reflects multiple pollution and genetic exchange among phyla from overlapping ecosystems

Revista: Science of The Total Environment

JCR (2019): 7.963

Referência Bibliográfica: Rebelo, A., Mourão, J., Freitas, A. R., Duarte, B., Silveira, E., Sanchez-Valenzuela, A., Almeida, A., Baquero, F., Coque, T. M., Peixe, L., Antunes, P., & Novais, C. (2021). Diversity of metal and antibiotic resistance genes in Enterococcus spp. from the last century reflects multiple pollution and genetic exchange among phyla from overlapping ecosystems. Science of The Total Environment, 787, 147548. https://doi.org/10.1016/j.scitotenv.2021.147548

 

The use of the CINtec® PLUS Cytology Kit as a complementary method of diagnosis is intended to contribute to a risk assessment of CIN II+ cervical lesions development, thus avoiding unnecessary colposcopy in negative cases. This method has proved to be effective in the follow-up of cervical lesions, although there is need for consistency in the approach of equivocal or negative cytological results, with persistent positive High-Risk Human Papillomavirus (HR-HPV) test. Aims: The present study intends to retrospectively evaluate the capacity of the CINtec® to add information to the clinical practice within the screening and follow-up of cervical lesions. Additionally, this study intends to define criteria for CINtec® referral in order to maximize its utilization in the Portuguese context. Materials and Methods: For this purpose, 225 cases with CINtec® PLUS Cytology Kit and histology results were used, and data were analysed and compared according to the cytology and HR-HPV molecular test results. Results: The data of this study show that CINtec® PLUS Cytology Kit is a valid test for the diagnosis of persistent HPV lesions (p = 0.0005), with excellent sensitivity and reliable values of specificity. Relevant patient groups to apply the kit are in agreement with the manufacturer recommendations: women with ASC-US/LSIL result and NILM cytology with HPV-positive test, essentially over 30 years old. Conclusions: Although clinical data and previous cytological information must help guiding, authors considered that CINtec® is a really valid test for the prognosis of persistent HPV infections in the female population. 

Título: Validation of CINtec® PLUS cytology kit in the diagnosis of persistent HPV infections - Cohort study in the Portuguese population

Revista: Journal of Cytology

JCR (2019): 1.000

Referência Bibliográfica: Abreu ÂL, Silva RA, Fernandes S. Validation of CINtec® PLUS cytology kit in the diagnosis of persistent HPV infections - Cohort study in the Portuguese population. J Cytol [serial online] 2021 [cited 2021 Jul 21];38:94-100. Available from: https://www.jcytol.org/text.asp?2021/38/2/94/315771

 

The relevance of ionic liquids (ILs) is now well established in many fields, as their unique properties make them appealing as 1) greener alternatives to organic solvents (first-generation ILs), 2) tunable task-specific materials (second-generation ILs), and 3) multifunctional players in life and pharmaceutical sciences (third-generation ILs). This third wave of ILs encompasses a wide range of compounds, from bioactive molecules with single or even dual therapeutic action, to potential ingredient molecules for drug formulation and transport systems. In this context, the focus of this review is the emergent role of surface-active ionic liquids (SAILs) in drug development and delivery.

Título: Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface-Active Ionic Liquids in Drug Development and Delivery

Revista: ChemMedChem

JCR (2019): 3.124

Referência Bibliográfica: Silva, A. T., Teixeira, C., Marques, E. F., Prudêncio, C., Gomes, P., & Ferraz, R. (2021). Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface-Active Ionic Liquids in Drug Development and Delivery [https://doi.org/10.1002/cmdc.202100215]. ChemMedChem, n/a(n/a). https://doi.org/10.1002/cmdc.202100215

 

The number of patients surviving severe brain injury is increasing; however, many are left in a prolonged disorder of consciousness. With appropriate treatment, patients with prolonged disorders of consciousness can survive for years. Unless an advance directive exists, the treating clinicians can authorize withdrawal of clinically assisted nutrition and hydration for these patients, based on best interests. The classic terminology used in prolonged disorders of consciousness ranges from coma, vegetative state to minimally conscious state. However, a new group of patients with covert cognition has been identified in the last decade, making it necessary to revise the current taxonomy to better reflect our understanding of these conditions. With the introduction of a less ambiguous terminology, the challenges when it comes to withdrawal of clinically assisted nutrition and hydration of these patients may ease. A decision- making pathway for withdrawal of clinically assisted nutrition and hydration for patients with prolonged disorders of consciousness, based on a new taxonomy is proposed. These decisions should be based primarily on best interests. The adoption of a new classification for impairments of consciousness would clarify and improve how we think about these patients. Moreover, the development of accurate prognostic predictors would be a major step in the decision-making process, as it would influence the beneficent pathway towards the best clinical outcome.

Título: New taxonomy for prolonged disorders of consciousness may help with decisions on withdrawal of clinically assisted nutrition and hydration: A proposed decision-making pathway

Revista: Journal of Rehabilitation Medicine

JCR (2019): 2.046

Referência Bibliográfica: Teixeira, L. d. C. R., Nuno Barbosa; Nunes, Rui. (2021). NEW TAXONOMY FOR PROLONGED DISORDERS OF CONSCIOUSNESS MAY HELP WITH DECISIONS ON WITHDRAWAL OF CLINICALLY ASSISTED NUTRITION AND HYDRATION: A PROPOSED DECISION-MAKING PATHWAY. Journal of Rehabilitation Medecine, 53(5). https://doi.org/10.2340/16501977-2834

 

Analysis of retinal microaneurysm turnover (MAT) has been previously shown to contribute to the identification of eyes at risk of developing clinically significant complications associated with diabetic retinopathy (DR). We propose to further characterize MAT as a predictive biomarker of DR progression and development of vision-threatening complications. Methods: 212 individuals with type 2 diabetes (T2D; ETDRS grades 20 and 35) were evaluated annually in a 5-year prospective, longitudinal study, by color fundus photography and optical coherence tomography. Endpoints were diabetic macular edema (DME) or proliferative retinopathy (PDR). MAT analysis included determination of MA formation and disappearance rates, automatically assessed using the RetMarkerDR®. Retinopathy severity progression was evaluated using step increases in ETDRS severity levels. Of the 212 individuals, 172 completed the 5-year follow-up study or developed an endpoint (n = 27). MAT calculated at 1 year showed a significant difference between groups of endpoint developments (p = 0.018), particularly MA disappearance rate (p = 0.007). MAT also showed a significant difference between eyes with different ETDRS severity progression in the 5-year period (p = 0.035). MAT is an indicator of the development of DME and/or PDR as well as of DR severity progression in T2D individuals with mild retinopathy.

Título: Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associated with Progression and Development of Vision-Threatening Complications: A 5-Year Longitudinal Study

RevistaJournal of Clinical Medicine

JCR (2019): 3.303

Referência Bibliográfica: Santos, A. R., Mendes, L., Madeira, M. H., Marques, I. P., Tavares, D., Figueira, J., Lobo, C., & Cunha-Vaz, J. (2021). Microaneurysm Turnover in Mild Non-Proliferative Diabetic Retinopathy is Associated with Progression and Development of Vision-Threatening Complications: A 5-Year Longitudinal Study. Journal of Clinical Medicine, 10(10), 2142. https://www.mdpi.com/2077-0383/10/10/2142

 

The adherence to inhaled controller medications is of critical importance for achieving good clinical results in patients with chronic respiratory diseases. Self-management strategies can result in improved health outcomes and reduce unscheduled care and improve disease control. However, adherence assessment suffers from difficulties on attaining a high grade of trustworthiness given that patient self-reports of high-adherence rates are known to be unreliable. Aiming to increase patient adherence to medication and allow for remote monitoring by health professionals, a mobile gamified application was developed where a therapeutic plan provides insight for creating a patient-oriented self-management system. To allow a reliable adherence measurement, the application includes a novel approach for objective verification of inhaler usage based on real-time video capture of the inhaler's dosage counters. Methods This approach uses template matching image processing techniques, an off-the-shelf machine learning framework, and was developed to be reusable within other applications. The proposed approach was validated by 24 participants with a set of 12 inhalers models. performed tests resulted in the correct value identification for the dosage counter in 79% of the registration events with all inhalers and over 90% for the three most widely used inhalers in Portugal. These results show the potential of exploring mobile-embedded capabilities for acquiring additional evidence regarding inhaler adherence. This system helps to bridge the gap between the patient and the health professional. By empowering the first with a tool for disease self-management and medication adherence and providing the later with additional relevant data, it paves the way to a better-informed disease management decision.

Título: InspirerMundi—Remote Monitoring of Inhaled Medication Adherence through Objective Verification Based on Combined Image Processing Techniques

Revista: Methods of Information in Medicine

JCR (2019): 1.574

Referência Bibliográfica: Vieira-Marques, P., Almeida, R., Teixeira, J. F., Valente, J., Jácome, C., Cachim, A., Guedes, R., Pereira, A., Jacinto, T., & Fonseca, J. A. (2021). InspirerMundi-Remote Monitoring of Inhaled Medication Adherence through Objective Verification Based on Combined Image Processing Techniques. Methods Inf Med. https://doi.org/10.1055/s-0041-1726277

 

Pain is the most feared and distressing symptom in palliative care. In advanced stages of cancer, its incidence is 70–80%. In Mozambique there is little published information concerning to the prevalence, intensity, and pain’s management in cancer patients. A cross-sectional observational study was conducted between August 2018 and January 2019, in Mozambique’s main hospitals, and in the only hospital with an isolated provision of palliative care service. The analyzed data included demographic data, pain intensity and its treatment. The Pain Management Index was used to calculate the adequacy of the analgesia. Results: A total of 294 patients were included. The mean patients’ age was 46.1 years old. Concerning to pain, 83.7% of the patients had pain, most of them moderate to severe pain. The prevalence of pain was frequent in women mainly in cervical cancer (84.3%) and in men with Kaposi sarcoma (80%). The main analgesic used for severe pain was paracetamol, and it was used alone in 40.9% of the patients. Morphine was used in 8.1% and adjuvants less than 10%. Pain Management Index was negative for 68.7% of the sample, meaning an inadequate analgesia. Significant differences were found in Pain Management Index levels between hospitals. The prevalence of pain in the main health institutions in Mozambique is high. Paracetamol was the analgesic most used in severe pain. Further studies are needed to understand the main reasons of patients’ suffering.

Título: Pain management in cancer patients in the main hospitals in Mozambique

Revista: Annals of Palliative Medicine

JCR (2019): 1.681

Referência Bibliográfica: Pinto, E., Gonçalves, F., Sacarlal, J., Castro, L., & Rego, G. (2021). Pain management in cancer patients in the main hospitals in Mozambique. Annals of Palliative Medicine, 10(4), 4069-4079. https://apm.amegroups.com/article/view/67519

 

Neurodegenerative diseases (NDs) represent a drawback in society given the ageing population. Dementias are the most prevalent NDs, with Alzheimer’s disease (AD) representing around 70% of all cases. The current pharmaceuticals for AD are symptomatic and with no effects on the progression of the disease. Thus, research on molecules with therapeutic relevance has become a major focus for the scientific community. Cyanobacteria are a group of photosynthetic prokaryotes rich in biomolecules with confirmed activity in pathologies such as cancer, and with feasible potential in NDs such as AD. In this review, we aimed to compile the research works focused in the anti-AD potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (BACE1) as a fundamental enzyme in the generation of β-amyloid (Aβ), the inhibition of the enzyme acetylcholinesterase (AChE) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms.

Título: Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease

Revista: Marine Drugs

JCR (2019): 4.073

Referência Bibliográfica: Castaneda, A., Ferraz, R., Vieira, M., Cardoso, I., Vasconcelos, V., & Martins, R. (2021). Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease. Marine Drugs, 19(6), 343. https://www.mdpi.com/1660-3397/19/6/343

 

Classification of asthma phenotypes has a potentially relevant impact on the clinical management of the disease. Methods for statistical classification without a priori assumptions (data-driven approaches) may contribute to developing a better comprehension of trait heterogeneity in disease phenotyping. This study aimed to summarize and characterize asthma phenotypes derived by data-driven methods. We performed a systematic review using three scientific databases, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. We included studies reporting adult asthma phenotypes derived by data-driven methods using easily accessible variables in clinical practice. Two independent reviewers assessed studies. The methodological quality of included primary studies was assessed using the ROBINS-I tool. We retrieved 7446 results and included 68 studies of which 65% (n = 44) used data from specialized centers and 53% (n = 36) evaluated the consistency of phenotypes. The most frequent data-driven method was hierarchical cluster analysis (n = 19). Three major asthma-related domains of easily measurable clinical variables used for phenotyping were identified: personal (n = 49), functional (n = 48) and clinical (n = 47). The identified asthma phenotypes varied according to the sample's characteristics, variables included in the model, and data availability. Overall, the most frequent phenotypes were related to atopy, gender, and severe disease. This review shows a large variability of asthma phenotypes derived from data-driven methods. Further research should include more population-based samples and assess longitudinal consistency of data-driven phenotypes.

 Título: A Systematic Review of Asthma Phenotypes Derived by Data-Driven Methods

Revista: Diagnostics

JCR (2019): 3.110

Referência Bibliográfica: Cunha, F., Amaral, R., Jacinto, T., Sousa-Pinto, B., & Fonseca, J. A. (2021). A Systematic Review of Asthma Phenotypes Derived by Data-Driven Methods. Diagnostics, 11(4). https://doi.org/10.3390/diagnostics11040644

 

Cyanobacteria are a group of photosynthetic prokaryotes that pose a great concern in the aquatic environments related to contamination and poisoning of wild life and humans. Some species of cyanobacteria produce potent toxins such as microcystins (MCs), which are extremely aggressive to several organisms, including animals and humans. In order to protect human health and prevent human exposure to this type of organisms and toxins, regulatory limits for MCs in drinking water have been established in most countries. In this regard, the World Health Organization (WHO) proposed 1 µg MCs/L as the highest acceptable concentration in drinking water. However, regulatory limits were not defined in waters used in other applications/activities, constituting a potential threat to the environment and to human health. Indeed, water contaminated with MCs or other cyanotoxins is recurrently used in agriculture and for crop and food production. Several deleterious effects of MCs including a decrease in growth, tissue necrosis, inhibition of photosynthesis and metabolic changes have been reported in plants leading to the impairment of crop productivity and economic loss. Studies have also revealed significant accumulation of MCs in edible tissues and plant organs, which raise concerns related to food safety. This work aims to systematize and analyze the information generated by previous scientific studies, namely on the phytotoxicity and the impact of MCs especially on growth, photosynthesis and productivity of agricultural plants. Morphological and physiological parameters of agronomic interest are overviewed in detail in this work, with the aim to evaluate the putative impact of MCs under field conditions. Finally, concentration-dependent effects are highlighted, as these can assist in future guidelines for irrigation waters and establish regulatory limits for MCs

Título: Impacts of Microcystins on Morphological and Physiological Parameters of Agricultural Plants: A Review

Revista: Plants

JCR (2019): 2.762

Referência Bibliográfica: Campos, A., Redouane, E. M., Freitas, M., Amaral, S., Azevedo, T., Loss, L., Máthé, C., Mohamed, Z. A., Oudra, B., & Vasconcelos, V. (2021). Impacts of Microcystins on Morphological and Physiological Parameters of Agricultural Plants: A Review. Plants, 10(4). https://doi.org/10.3390/plants10040639

 

No   specific   guidelines   for   the   management   of   functional   electrical stimulation (FES) parameters  in post  stroke patients  have  been defined yet,  despite  its frequent use.  The  purpose  of  this  study  is  to  characterize the  optimal  FES  parameters that assist the reaching phase of drinking task (“drinking task - reaching phase”) on post stroke subjects and to analyze the related upper limb (UL) movement quality indicators repeatability. An observational study with a test and re-test design involving ten post stroke subjects  with UL dysfunction was  performed.  End-point  and  joint  kinematics  of contralesional UL were  assessed during the “drinking task - reaching phase” with FES through a test and retest design. FES parameters were adjusted to improve UL function according to a consensus between physiotherapists‟ and patients‟ perspective.  Findings: It was possible to establish reliable FES parameters that assisted the “drinking task - reaching phase”. All FES parameters presented high to very high repeatability and led  to  moderate to  very  high  repeatability  in almost UL movement  quality  indicators during the “drinking task - reaching phase”. Interpretation: These findings show that the main characteristics of FES parameters that improves   patient   perception   of   change   are   quiet   stable,   which   facilitate   its implementation   in   clinical   practice   by   allowing   consistence   between   intervention sessions.  

Título: Optimal Multi-Field Functional Electrical Stimulation Parameters for the “Drinking Task - Reaching phase” and Related Upper Limb Kinematics Repeatability in Post stroke Subjects

Revista: Journal of Hand Therapy

JCR (2019): 1.504

Referência Bibliográfica: Sousa, A. S. P., da Silva, C. I. C., Mesquita, I. A., Silva, A., Macedo, R., Imatz-Ojanguren, E., Hernandez, E., Keller, T., Moreira, J., da Fonseca, P. F. P., & Santos, R. (2021). Optimal Multi-Field Functional Electrical Stimulation Parameters for the “Drinking Task - Reaching phase” and Related Upper Limb Kinematics Repeatability in Post stroke Subjects. Journal of Hand Therapy. https://doi.org/10.1016/j.jht.2021.05.002

 

The purpose of this study is to evaluate the effects of radiofrequency (RF) on sagging skin. This is a case series study with five volunteers who received a single application of capacitive RF (BTL-6000 TR-Therapy Pro®) in the right infraumbilical abdominal region, with epidermal temperature above 40°C, for 10 min (2 min per applicator area), and the skin of the contralateral region was used as control. After 30 days, on average, the skin of the abdominal region was collected for histological analysis and stained with hematoxylin and eosin, Picro-sirus, and Verhoff. The percentage of collagen and elastic fibers found was marked by the Image J®. The statistical analysis was performed in the SPSS program (version 20), with a significance level of 95%. This was registered with the ethics and research comitee of UFTM n 3.461.688 on Jul 12, 2019 and clinical trial registration n. NCT04182542, retrospectively registered. Morphometric analysis demonstrated a remodeling of collagen and elastic fibers on the side treated with RF; however, the morphometry for collagen showed no significant difference, with an average percentage of 60.94 ± 0.32 for the control side and 61.97 ± 2.80 for the treated with p=0.32. Similarly, elastic fibers also showed no significant difference between groups, with a mean percentage of 5.67 ± 2.70 for control and 6.21 ± 2.01 for treated with p=0.19. The RF with the parameters used in this study was able to cause morphological changes in collagen and elastic fibers of the abdominal region skin; however, it showed no change in the percentage of these fibers.

Título: Effect of capacitive radiofrequency on the dermis of the abdominal region

Revista: Lasers in Medical Science (2.342)

JCR (2019): 2.342

Referência Bibliográfica: Monaretti, G. L., Costa, M. C. F., Rocha, L. B., Cintra, M. M. M., da Cunha, M. T. R., Pinheiro, N. M., Noites, A., & Mendonça, A. C. (2021). Effect of capacitive radiofrequency on the dermis of the abdominal region. Lasers in Medical Science. https://doi.org/10.1007/s10103-021-03311-3

 

Physical distancing under the coronavirus disease 2019 (COVID-19) pandemic had a significant impact on lifestyles, including exercise routines. In this study, we examined the relationship between mental health and addictive behaviors, such as excessive exercise and the use of image and performance enhancing drugs (IPEDs) across 12 sport disciplines. Materials and methods: A large cross-sectional sample of the adult population (N = 2,295) was surveyed. The mean age was 33.09 (SD = 11.40). The number of male participants was 668 (30.0%). The use of IPEDs was assessed in conjunction with psychometric measures such as the Exercise Addiction Inventory (EAI) and the Shibata et al. Sports Disciplines and IPEDs Appearance Anxiety Inventory (AAI). The participants were grouped into activity group (AG) and non-activity group (NAG) according to the presence or absence of their exercise habits. The results were compared between these groups, as well as across sport disciplines, while taking into account the relationship between different psychological measures and IPEDs consumption. Results: The frequency of IPEDs use was higher among AG (34.6%) than NAG (14.6%), although AG participants reported less history of addictions (7.1%) than NAG (11.8%). The logistic regression analysis revealed that scores equal to or above cutoff points, in both the EAI and AAI, predicted the IPEDs use. Regarding the differences across the various sport disciplines, those who were involved in practicing Weight Lifting and Cross Fit were found to be more at risk of excessive exercising and more inclined to use a wide range of IPEDs. Conclusions: Although exercise could help to increase well-being and prevent addictions during the COVID-19 pandemic, our results show that those in the AG are particularly vulnerable to excessive IPEDs use. Sport disciplines associated with higher EAI and AAI scores have also shown a higher tendency to excessive IPEDs use. Furthermore, the factor of having above the cutoff scores in EAI or AAI in each sport could indicate larger IPEDs consumption regardless of the discipline. In light of the current findings, it is necessary to better define the “non-excessive” levels of exercise in various sport disciplines and an adequate intake of IPEDs to ensure the safety and well-being of people during a pandemic

Título: Exploring the Relationship Between Mental Well-Being, Exercise Routines, and the Intake of Image and Performance Enhancing Drugs During the Coronavirus Disease 2019 Pandemic: A Comparison Across Sport Disciplines

Revista: Frontiers in Psychology

JCR (2019): 2.990

Referência Bibliográfica: Shibata,  M., Burkauskas J., Dores A. R.*, Kobayashi K., Yoshimura, S., Simonato, P., … Corazza,  O. (2021). Exploring the relationship between mental wellbeing, exercise routines and the intake of Image and Performance Enhancing Drugs during the COVID-19 pandemic: a comparison across sport disciplines, Frontiers in Psychology, section Movement Science and Sport Psychology https://doi.org/10.3389/fpsyg.2021.689058

 

In this study we examined whether parents’ perceptions of students’ anxiety as well as perceived support from both teachers and classmates were predictive of changes in students’ academic motivation during the first wave of COVID-19. To this end, we used a retrospective pretest-posttest design together with a latent change score model to analyze our data.

Título: Anxiety and social support as predictors of student academic motivation during the COVID-19

Revista: Frontiers in Psychology

JCR (2019): 2.067

Referência Bibliográfica Camacho, A., Correia, N., Zaccoletti, S., & Daniel, J. R. (2021). Anxiety and social support as predictors of student academic motivation during the COVID-19. Frontiers in Psychology, 12(1894). https://doi.org/10.3389/fpsyg.2021.644338

 

The COVID-19 global pandemic brought several challenges to occupational safety and health practice. One of these is the need to (re)assess the occupational risks, particularly, biological risks.

Título: Biological risk assessment: a challenge for occupational health and safety practitioners during Covi-19 (Sars-CoV-2) Pandemic

Revista:  WORK

JCR (2019):  1132

Referência bibliográfica: Carvalhais, Carlos et al. ‘Biological Risk Assessment: A Challenge for Occupational Health and Safety Practitioners During the COVID-19 (SARS-CoV-2) Pandemic’. 1 Jan. 2021 : 1 – 11

 

The coronavirus disease 2019 outbreak forced most of the world’s population to be confined at home to prevent contagion.

Título:  Are Emotional and Behavioral Problems of Infants and Children Aged Younger Than 7 Years Related to Screen Time Exposure During the Coronavirus Disease 2019 Confinement? An Exploratory Study in Portugal

Revista: Frontiers in psychology

JCR (2019): 2.067

Referência Bibliográfica: Infants and Children Aged Younger Than 7 Years Related to Screen Time Exposure During the Coronavirus Disease 2019 Confinement? An Exploratory Study in Portugal [Brief Research Report]. Frontiers in Psychology, 12(344). https://doi.org/10.3389/fpsyg.2021.590279

 

O artigo apresenta uma revisão das principais características das tarefas de Integração Multissensorial e sua utilidade na avaliação cognitiva e da funcionalidade de idosos com ou sem comprometimento neurocognitivo. Além disso, analisa o potencial da inclusão de tarefas de avaliação da Integração Multissensorial no aumento da validade ecológica dos protocolos de avaliação neuropsicológica de idosos, tendo como enquadramento teórico o modelo neurocognitivo de Luria.

Título: Narrative review of the multisensory integration tasks used with older adults: inclusion of multisensory integration tasks into neuropsychological assessment

Revista: Expert review of neurotherapeutics

JCR (2019): 3.743

Referência bibliográfica: Joana O. Pinto, Bruno B. Vieira De Melo, Artemisa R. Dores*, Bruno Peixoto, Andreia Geraldo & Fernando Barbosa (2021) Narrative review of the multisensory integration tasks used with older adults: inclusion of multisensory integration tasks into neuropsychological assessment, Expert Review of Neurotherapeutics, DOI: 10.1080/14737175.2021.1914592. https://doi.org/10.1080/14737175.2021.1914592

 

This research work aims the development and optimization of an electrochemical biosensor based on molecularly-imprinted polymers [MIPs], for monitoring a melanoma biomarker, Galectin-3 (Gal-3).

Título: Development of an electrochemical biosensor for Galectin-3 detection in point-of-care

Revista: Microchemical Journal

JCR (2019): 3.594

Referência bibliográfica: Cerqueira, S. M. V., Fernandes, R., Moreira, F. T. C., & Sales, M. G. F. (2021). Development of an electrochemical biosensor for Galectin-3 detection in point-of-care. Microchemical Journal, 164, 105992. https://doi.org/https://doi.org/10.1016/j.microc.2021.105992

 

Auditory event-related potentials (ERP) may serve as diagnostic tools for schizophrenia and inform on the susceptibility for this condition.

Título: Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia

Revista: Frontiers in Psychiatry

JCR (2019): 2.849

Referência Bibliográfica: Mazer, P., Macedo, I., Paiva, T. O., Ferreira-Santos, F., Pasion, R., Barbosa, F., Almeida, P., Silveira, C., Cunha-Reis, C., & Marques-Teixeira, J. (2021). Abnormal Habituation of the Auditory Event-Related Potential P2 Component in Patients With Schizophrenia [Brief Research Report]. Frontiers in Psychiatry, 12(297). https://doi.org/10.3389/fpsyt.2021.630406

 

Chester step test (CST) estimates the exercise capacity through a submaximal response, which can limit its application in the prescription of exercise.

Título: Adapted Chester Step Test Can Have Maximal Response Characteristics for the Assessment of Exercise Capacity in Young Women

Revista: Healthcare

JCR (2019): 1.960

Referência bibliográfica: Characteristics for the Assessment of Exercise Capacity in Young Women. Healthcare, 9(3), 308. https://www.mdpi.com/2227-9032/9/3/308

 

This study aims to determine the guidelines for the design of a social skills training programme for people with schizophrenia using virtual reality.

Título: Virtual reality in social skills training programs for people with schizophrenia: A systematic review and focus group

Revista: British Journal of Occupational Therapy

JCR (2019): 0.960

Referência bibliográfica: Oliveira, C., Simões de Almeida, R., & Marques, A. (2021). Virtual reality in social skills training programs for people with schizophrenia: A systematic review and focus group. British Journal of Occupational Therapy. https://doi.org/10.1177/03080226211011391

 

A empatia é reconhecida como um elemento essencial da comunicação clínica e na prestação de cuidados de saúde. É importante que as instituições de Ensino Superior a valorizem nos seus curricula e preparem os estudantes para as exigências académicas e da futura atividade profissional, nomeadamente através do recurso a estratégias de coping adaptativas.

Este estudo teve como objetivo estudar os padrões de associações entre empatia e coping, em estudantes do género feminino e masculino, da área de Tecnologias da Saúde.

Título: Empathy and coping strategies in allied health sciences: Gender patterns

Revista: Healthcare

JCR (2019):  1.916

Referência bibliográfica: Dores, A. R.*, Martins, H., Reis, A.C., & Carvalho, I. P. (2021). Empathy and coping strategies in allied health sciences: Gender patterns. Healthcare, 9, 497. https://doi.org/10.3390/healthcare9050497 (ANEXO PUBL_16) https://www.mdpi.com/2227-9032/9/5/497

 

Este estudo analisou as relações estruturais entre duas variáveis motivacionais (viz., autoeficácia e atitudes face à escrita), frequência de escrita e qualidade textual em alunos portugueses do 5.º ao 8.º ano de escolaridade. Os resultados evidenciaram que atitudes mais positivas face à escrita estão associadas com uma maior frequência de escrita dos alunos, bem como com melhores textos narrativos e de opinião. Por seu turno, maior autoeficácia para autorregular o comportamento durante a escrita também contribui de forma significativa para melhores textos narrativos. Globalmente, este estudo aponta para a necessidade de os professores adotarem práticas motivacionais no ensino da escrita, que promovam atitudes positivas face à escrita e a autoeficácia de alunos de diferentes níveis de escolaridade.

Título: Relations among motivation, behaviour, and performance in writing: A multiple-group structural equation modeling study

Revista: British Journal of Educational Psychology

JCR (2019): 2.506

Referência bibliográfica: Camacho, A., Alves, R. A., De Smedt, F., Van Keer, H., & Boscolo, P. (2021). Relations among motivation, behaviour, and performance in writing: A multiple-group structural equation modeling study. British Journal of Educational Psychology. Advance online publication. https://doi.org/10.1111/bjep.12430

 

Título: Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies

Revista: International Journal of Environmental Research and Public Health

JCR (2018): 2.468

Referência bibliográfia: Amaral, R., Jácome, C., Almeida, R., Pereira, A. M., Alves-Correia, M., Mendes, S., Rodrigues, J. C., Carvalho, J., Araújo, L., Costa, A., Silva, A., Teixeira, M. F., Ferreira-Magalhães, M., Alves, R. R., Moreira, A. S., Fernandes, R. M., Ferreira, R., Pinto, P. L., Neuparth, N., Bordalo, D., Bom, A. T., Cálix, M. J., Ferreira, T., Gomes, J., Vidal, C., Mendes, A., Vasconcelos, M. J., Silva, P. M., Ferraz, J., Morête, A., Pinto, C. S., Santos, N., Loureiro, C. C., Arrobas, A., Marques, M. L., Lozoya, C., Lopes, C., Cardia, F., Loureiro, C. C., Câmara, R., Vieira, I., Silva, S. D., Silva, E., Rodrigues, N., & Fonseca, J. A. (2021). Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies. International Journal of Environmental Research and Public Health, 18(3). https://doi.org/10.3390/ijerph18031015

 

Título: Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice

Revista: Pharmaceuticals

JCR (2019): 4.286

Referência bibliográfica: Vojtek, M., Gonçalves-Monteiro, S., Pinto, E., Kalivodová, S., Almeida, A., Marques, M. P. M., Batista de Carvalho, A. L. M., Martins, C. B., Mota-Filipe, H., Ferreira, I. M. P. L. V. O., & Diniz, C. (2021). Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd2Spm) in Mice. Pharmaceuticals, 14(2). https://doi.org/10.3390/ph14020173

 

Título: Effect of Metabolic Syndrome and Individual Components on Colon Cancer Characteristics and Prognosis

Revista: Frontiers in Oncology

JCR (2019): 4.848

Referência Bibliográfica: Silva, A., Pereira, S. S., Monteiro, M. P., Araújo, A., & Faria, G. (2021). Effect of Metabolic Syndrome and Individual Components on Colon Cancer Characteristics and Prognosis. Frontiers in oncology, 11, 631257-631257. https://doi.org/10.3389/fonc.2021.631257

 


Título: Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier

Revista: Drug Delivery and Translational Research

JCR (2019): 2.669

Referência Bibliográfica: Oliveira, A. I., Pinho, C., Sarmento, B., & Dias, A. C. P. (2021). Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier. Drug Delivery and Translational Researchhttps://doi.org/10.1007/s13346-021-00917-6

 

Título: Assessing the efficacy and feasibility of providing metacognitive training for patients with schizophrenia by mental health nurses: A randomized controlled trial

 Revista: Journal of Advanced Nursing

JCR (2019): 2.561

Referência bibliográfica: de Pinho, L. M. G., Sequeira, C. A. d. C., Sampaio, F. M. C., Rocha, N. B., Ozaslan, Z., & Ferre-Grau, C. (2020, 2020/11/22). Assessing the efficacy and feasibility of providing metacognitive training for patients with schizophrenia by mental health nurses: A randomized controlled trial [https://doi.org/10.1111/jan.14627]. Journal of Advanced Nursing, n/a(n/a). https://doi.org/10.1111/jan.14627

 

Título: On the nature of fear and anxiety triggered by COVID-19

Revista: Frontiers in Psychology

 JCR (2019): 2.067

Referência bibliográfica: Coelho, C. M., Suttiwan, P., Arato, N., & Zsido, A. N. (2020, 2020-November-09). On the Nature of Fear and Anxiety Triggered by COVID-19 [Review]. Frontiers in Psychology, 11(3109). https://doi.org/10.3389/fpsyg.2020.581314

 

Título: Response to: Models and theoretical frameworks for osteopathic care - A critical view and call for updates and research

Revista: International Journal of Osteopathic Medicine

JCR (2019): 1.208

Referência bibliográfica: Santiago, R., Campos, B., Moita, J., & Nunes, A. (2020, 2020/09/01/). Response to: Models and theoretical frameworks for osteopathic care - A critical view and call for updates and research. International Journal of Osteopathic Medicine, 37, 52-53. https://doi.org/10.1016/j.ijosm.2020.07.001

 

Título: Mesenchymal Stem Cells (MSCs) as a potential therapeutic Strategy in COVID-19 Patients: Literature Research

Revista: Frontiers in Cell and Developmental Biology

 JCR (2019): 5.201

Referência bibliográfica: Coelho, A., Alvites, R. D., Branquinho, M. V., Guerreiro, S. G., & Maurício, A. C. (2020, 2020-November-19). Mesenchymal Stem Cells (MSCs) as a Potential Therapeutic Strategy in COVID-19 Patients: Literature Research [Review]. Frontiers in Cell and Developmental Biology, 8(1392). https://doi.org/10.3389/fcell.2020.602647

 

Título: 4,9-Diaminoacridines and 4-Aminoacridines as Dual-Stage Antiplasmodial Hits

Revista: ChemMedChem

 JCR (2019): 3.124

Referência bibliográfica: Fonte, M., Tassi, N., Fontinha, D., Bouzón-Arnáiz, I., Ferraz, R., Araújo, M. J., Fernàndez-Busquets, X., Prudêncio, M., Gomes, P., & Teixeira, C. (2020, 2020/11/20). 4,9-Diaminoacridines and 4-Aminoacridines as Dual-Stage Antiplasmodial Hits [https://doi.org/10.1002/cmdc.202000740]. ChemMedChem, n/a(n/a). https://doi.org/10.1002/cmdc.202000740 

 

Título: Resolution of chronic lower back pain symptoms through high-intensity therapeutic exercise and motor imagery program: a case-report

Revista: Physiotherapy Theory and Practice

 JCR (2019): 1.624

Referência bibliográfica: Ribas, J., Gomes, M. A., Montes, A. M., Ribas, C., & Duarte, J. A. (2020). Resolution of chronic lower back pain symptoms through high-intensity therapeutic exercise and motor imagery program: a case-report. Physiotherapy Theory and Practice, 1-8. https://doi.org/10.1080/09593985.2020.1839985

 

Título: Abdominal muscle activity and pelvic motion according to active straight leg raising test results in adults with and without chronic low back pain

Revista: Musculoskeletal Science and Practice

JCR (2019): 1.911 

Referência bibliográfica: Crasto, C., Montes, A. M., Carvalho, P., & Carral, J. M. C. (2020, 2020/12/01/). Abdominal muscle activity and pelvic motion according to active straight leg raising test results in adults with and without chronic low back pain. Musculoskeletal Science and Practice, 50, 102245. https://doi.org/10.1016/j.msksp.2020.102245

 

Este estudo analisou o impacto da pandemia na motivação académica de alunos portugueses e italianos do 1.º ao 9.º ano, recorrendo aos pais como informantes. Os resultados mostraram que a motivação dos alunos diminuiu durante o confinamento. Este decréscimo foi mais acentuado em alunos italianos e mais novos. O estudo indicou também que uma menor participação em atividades extracurriculares durante o confinamento estava associada ao declínio da motivação académica.

Título: Parents’ perceptions of student academic motivation during the COVID-19 lockdown: A cross-cultural comparison

Revista: Frontiers in Psychology

JCR (2019): 2.067

Referência bibliográfica: Zaccoletti, S.*, Camacho, A.*, Correia, N., Aguiar, C., Mason, L., Alves, R. A., & Daniel, J. R. (2020). Parents’ perceptions of student academic motivation during the COVID-19 lockdown: A cross-country comparison. Frontiers in Psychology11(3602). https://doi.org/10.3389/fpsyg.2020.592670 *Joint first authors 

*ATC de CSH, Dra Ana Camacho

 

 

Este estudo teve como objetivo estudar a associação entre stresse percebido, coping, desregulação emocional, afeto e sintomas psicossomáticos no Ensino Superior. Os participantes preencheram a Escala de Stresse Percebido, o Brief-COPE, a Escala de Dificuldades na Regulação Emocional, o PANAS e o Questionário de Manifestações de Desconforto Físico. Foram identificadas diferenças de género significativas no stresse percebido e nos sintomas psicossomáticos (ambos mais elevados nas mulheres), e no coping (estratégias de apoio emocional vs humor mais altas em mulheres e homens, respetivamente). Os resultados podem encorajar as instituições a promover programas de desenvolvimento que visem a regulação emocional para apoiar os estudantes na transição para o ensino superior.

Título: Academic stress, coping, emotion regulation, affect and psychosomatic symptoms in higher education

Revista: Current Psychology

JCR (2019): 2.051

Referência bibliográfica: Teixeira, R.J., Brandão, T. & Dores, A.R.* Academic stress, coping, emotion regulation, affect and psychosomatic symptoms in higher education. Curr Psychol (2021). https://doi.org/10.1007/s12144-020-01304-z

 *Artemisa R Dores - artemisa@ess.ipp.pt

Home page: https://www.springer.com/journal/12144

 

Título: Azadirachta indica A. Juss. In Vivo Toxicity—An Updated Review

Revista: Molecules

JCR (2019): 3.267

Referência bibliográfica: Braga, T. M., Rocha, L., Chung, T. Y., Oliveira, R. F., Pinho, C., Oliveira, A. I., Morgado, J., & Cruz, A. (2021). Azadirachta indica A. Juss. In Vivo Toxicity—An Updated Review. Molecules, 26(2). https://doi.org/10.3390/molecules26020252

 

Título: How can Environmental Health Practitioners contribute to ensure population safety and health during the COVID-19 pandemic?

Revista: Safety Science

JCR (2019): 4.105

Referência bibliográfica: Rodrigues, M. A., Silva, M. V., Errett, N. A., Davis, G., Lynch, Z., Dhesi, S., Hannelly, T., Mitchell, G., Dyjack, D., & Ross, K. E. (2020, 2020/12/26/). How can Environmental Health Practitioners contribute to ensure population safety and health during the COVID-19 pandemic? Safety Science, 105136. https://doi.org/https://doi.org/10.1016/j.ssci.2020.105136

 

Título: Promoting Reminiscences with Virtual Reality Headsets: A Pilot Study with People with Dementia

Revista: International Journal of Environmental Research and Public Health

JCR (2019): 2.849

Referência bibliográfica: Coelho, T., Marques, C., Moreira, D., Soares, M., Portugal, P., Marques, A., Ferreira, A. R., Martins, S., & Fernandes, L. (2020). Promoting Reminiscences with Virtual Reality Headsets: A Pilot Study with People with Dementia. International Journal of Environmental Research and Public Health, 17(24), 9301. https://www.mdpi.com/1660-4601/17/24/9301

 

O objetivo deste estudo foi calcular a validade de constructo, consistência interna e dados normativos do Teste de Fluência Verbal Fonológica (letras F, A, S e M), do Teste de Fluência Verbal Semântica (categorias Animais, Frutas e Profissões), e do Teste de Nomeação de Boston. Os dados normativos consideram a idade, educação e sexo. Uma amostra de 293 adultos portugueses europeus participou no estudo. Os dados normativos disponibilizados contribuirão para a melhoria da prática clínica na área da neuropsicologia em Portugal.

Título: Normative data for Verbal Fluency and Object Naming Tests in a sample of European Portuguese adult population, Applied Neuropsychology

Revista: Applied Neuropsychology: Adult

JCR (2019): 1.488

Referência bibliográfica: Selene G. Vicente, Itziar Benito-Sánchez, Fernando Barbosa, Nuno Gaspar, Artemisa R. Dores*, Diego Rivera & Juan Carlos Arango-Lasprilla (2021) Normative data for Verbal Fluency and Object Naming Tests in a sample of European Portuguese adult population, Applied Neuropsychology: Adult, DOI: https://doi.org/10.1080/23279095.2020.1868472

* Artemisa R Dores, ATC de CSH - artemisa@ess.ipp.pt

 

O confinamento aumenta a ansiedade com a aparência física, levando à utilização problemática de produtos para melhorar a imagem e o desempenho. O estudo, liderado pela Universidade de Hertfordshire, do Reino Unido, revelou que 20% dos participantes utilizaram produtos para melhorar a imagem e o desempenho durante a pandemia da COVID-19, tendo sido esse valor de 18% em Portugal.

Título: Exercise and Use of Enhancement Drugs at the Time of the COVID-19 Pandemic: A Multicultural Study on Coping Strategies During Self-Isolation and Related Risks

JCR (2019): 2.849

Revista: Frontiers in Psychology

Referência Bibliográfica: Dores, A. R., Carvalho, I. P., Burkauskas, J., Simonato, P., De Luca, I., Mooney, R., Ioannidis, K., Gómez-Martínez, M. Á., Demetrovics, Z., Ábel, K. E., Szabo, A., Fujiwara, H., Shibata, M., Ventola, A. R. M., Arroyo-Anlló, E. M., Santos-Labrador, R. M., Griskova-Bulanova, I., Pranckeviciene, A., Kobayashi, K., Martinotti, G., Fineberg, N. A., Barbosa, F., & Corazza, O. (2021). Exercise and Use of Enhancement Drugs at the Time of the COVID-19 Pandemic: A Multicultural Study on Coping Strategies During Self-Isolation and Related Risks [Original Research]. Frontiers in Psychiatry, 12(165). https://doi.org/10.3389/fpsyt.2021.648501